CAJ | 학술논문

目的：探讨典型抗精神病药物与非典型抗精神病药物对精神分裂症患者认知功能的作用。方法将我院2010-01-2012-01收治的98例精神分裂症患者随机分为对照组与观察组，分别给予典型抗精神病药物（氯丙嗪）与非典型抗精神病药物（阿哌唑）治疗，采用威斯康星卡片分类测试（WCST ）评定2组基线和治疗后认知功能的差异。结果观察组治疗后WCST各项评分均较基线时和对照组明显改善，差异有统计学意义（P＜0.05）。结论非典型抗精神病药物可明显改善精神分裂症患者认知功能，具有较好的临床应用价值。
목적：탐토전형항정신병약물여비전형항정신병약물대정신분렬증환자인지공능적작용。방법장아원2010-01-2012-01수치적98례정신분렬증환자수궤분위대조조여관찰조，분별급여전형항정신병약물（록병진）여비전형항정신병약물（아고서）치료，채용위사강성잡편분류측시（WCST ）평정2조기선화치료후인지공능적차이。결과관찰조치료후WCST각항평분균교기선시화대조조명현개선，차이유통계학의의（P＜0.05）。결론비전형항정신병약물가명현개선정신분렬증환자인지공능，구유교호적림상응용개치。
Objective To explore the effect of classical antipsychotics and non -classical antipsychotic drugs on cognitive function in patients with schizophrenia .Methods 98 patients with schizophrenia in our hospital from January 2010 to 2012 Jan-uary were randomly divided into control group and observation group ,and they were given the classic antipsychotics (chlor-promazine) and non-classical antipsychotics (alicante prazosin) for treatment ,the Wisconsin Card Sorting Test (WCST ) were used for testing the baseline and post-treatment differences in cognitive function .Results After treatment ,the WCST scores had improved more significantly than that on baseline and that of the control group ,the difference was statistically significant (P<0 .05) .Conclusion Non-classical antipsychotic drugs can significantly improve cognitive function in patients with schizo-phrenia ,and it has better clinical value .