中国实用神经疾病杂志
中國實用神經疾病雜誌
중국실용신경질병잡지
CHINESE JOURNAL OF PRACTICAL NERVOUS DISEASES
2014年
12期
42-43
,共2页
刘威%吕娟%刘荣丽%李江涛
劉威%呂娟%劉榮麗%李江濤
류위%려연%류영려%리강도
阿托伐他汀钙%脑梗死%颈动脉粥样硬化斑块%血清C反应蛋白(CRP)
阿託伐他汀鈣%腦梗死%頸動脈粥樣硬化斑塊%血清C反應蛋白(CRP)
아탁벌타정개%뇌경사%경동맥죽양경화반괴%혈청C반응단백(CRP)
atorvastatin calcium infarction%carotid atherosclerotic plaques%serum C-reactive protein (CRP)
目的：探讨阿托伐他汀钙对脑梗死并发颈动脉粥样硬化斑块及血清C反应蛋白（CRP）的影响。方法将我院2012-01-2013-01收治的86例脑梗死患者按照入院先后顺序随机分为2组，每组各43例，其中对照组给予肠溶阿司匹林治疗，观察组在对照组基础上加用阿托伐他汀钙，比较2组治疗前后颈动脉内-中膜（IM T ）厚度和斑块面积及CRP水平变化。结果观察组治疗后颈动脉IM T和斑块面积分别为（1.22±0.20）mm和（17.18±2.01）mm2，均显著低于治疗前的（1.50±0.21）mm和（24.93±2.10）mm2及对照组的（1.45±0.21）mm和（24.20±2.21）mm2，差异均具有统计学意义（P＜0.05）；观察组治疗后CRP水平为（5.36±0.63）mg／L ，均显著低于治疗前的（10.82±1.11）mg／L和对照组的（10.13±1.08）mg／L ，差异均具有统计学意义（ P＜0.05）。结论阿托伐他汀钙治疗脑梗死并发颈动脉粥样硬化效果显著，可有效稳定动脉粥样硬化斑块及抑制炎症反应，具有较好的临床效果。
目的：探討阿託伐他汀鈣對腦梗死併髮頸動脈粥樣硬化斑塊及血清C反應蛋白（CRP）的影響。方法將我院2012-01-2013-01收治的86例腦梗死患者按照入院先後順序隨機分為2組，每組各43例，其中對照組給予腸溶阿司匹林治療，觀察組在對照組基礎上加用阿託伐他汀鈣，比較2組治療前後頸動脈內-中膜（IM T ）厚度和斑塊麵積及CRP水平變化。結果觀察組治療後頸動脈IM T和斑塊麵積分彆為（1.22±0.20）mm和（17.18±2.01）mm2，均顯著低于治療前的（1.50±0.21）mm和（24.93±2.10）mm2及對照組的（1.45±0.21）mm和（24.20±2.21）mm2，差異均具有統計學意義（P＜0.05）；觀察組治療後CRP水平為（5.36±0.63）mg／L ，均顯著低于治療前的（10.82±1.11）mg／L和對照組的（10.13±1.08）mg／L ，差異均具有統計學意義（ P＜0.05）。結論阿託伐他汀鈣治療腦梗死併髮頸動脈粥樣硬化效果顯著，可有效穩定動脈粥樣硬化斑塊及抑製炎癥反應，具有較好的臨床效果。
목적：탐토아탁벌타정개대뇌경사병발경동맥죽양경화반괴급혈청C반응단백（CRP）적영향。방법장아원2012-01-2013-01수치적86례뇌경사환자안조입원선후순서수궤분위2조，매조각43례，기중대조조급여장용아사필림치료，관찰조재대조조기출상가용아탁벌타정개，비교2조치료전후경동맥내-중막（IM T ）후도화반괴면적급CRP수평변화。결과관찰조치료후경동맥IM T화반괴면적분별위（1.22±0.20）mm화（17.18±2.01）mm2，균현저저우치료전적（1.50±0.21）mm화（24.93±2.10）mm2급대조조적（1.45±0.21）mm화（24.20±2.21）mm2，차이균구유통계학의의（P＜0.05）；관찰조치료후CRP수평위（5.36±0.63）mg／L ，균현저저우치료전적（10.82±1.11）mg／L화대조조적（10.13±1.08）mg／L ，차이균구유통계학의의（ P＜0.05）。결론아탁벌타정개치료뇌경사병발경동맥죽양경화효과현저，가유효은정동맥죽양경화반괴급억제염증반응，구유교호적림상효과。
Objective To investigate the effects of atorvastatin calcium on cerebral infarction complicated with carotid ath-erosclerotic plaque and serum C-reactive protein (CRP).Methods 86 patients with cerebral infarction in our hospital from Jan-uary 2012 to January 2013 were randomly divided into two groups according to admission order ,each of the group had 43 ca-ses.The control group was given the therapy of enteric aspirin while the study group was given atorvastatin calcium on basis of the control group ,the thickness of carotid IM T ,plaque area and CRP levels were compared before and after treatment.Results The carotid IMT and plaque area were (1.22 ± 0.20) mm and (17.18 ± 2.01) mm2 which were significantly lower than prior treatment's (1.50 ± 0.21) mm and (24.93 ± 2.10) mm2 ,and the control group's (1.45 ± 0.21) mm and (24.20 ± 2.21) mm2 , the differences were statistically significant (P<0.05);The CRP levels of the study group after treatment was (5.36 ± 0.63) mg/L ,which was significantly lower than the prior treatment of (10.82 ± 1.11) mg/L and the control group's (10.13 ± 1.08) mg/L ,the differences were statistically significant (P<0.05).Conclusion The effect of atorvastatin calcium on cerebral infarc-tion complicated with carotid atherosclerosis is significantly better and it can effectively stabilize atherosclerotic plaques and re-strain the inflammatory response ,is worth of spreading in clinics .
