中国实用神经疾病杂志
中國實用神經疾病雜誌
중국실용신경질병잡지
CHINESE JOURNAL OF PRACTICAL NERVOUS DISEASES
2014年
12期
34-36
,共3页
急性脑出血%神经节苷脂钠(GM1)%依达拉奉%日常生活活动能力%脑水肿
急性腦齣血%神經節苷脂鈉(GM1)%依達拉奉%日常生活活動能力%腦水腫
급성뇌출혈%신경절감지납(GM1)%의체랍봉%일상생활활동능력%뇌수종
Acute cerebral hemorrhage%Monosialotetrahexosyl ganglioside sodium%Edaravone%Activities of daily living%Cerebral edema
目的：观察单唾液酸四己糖神经节苷脂钠（GM1）联合依达拉奉在急性脑出血治疗中的应用效果。方法选取我院2009-01-2012-01收治的102例急性脑出血患者，随机分为对照组（n＝50）与观察组（n＝52），对照组在常规治疗基础上加用依达拉奉注射液30 mg＋0.9％氯化钠注射液100 mL静滴，2次／d ，观察组在对照组基础上给予GM1100 mg＋0.9％氯化钠注射液250 mL静滴，1次／d ，2组均连续治疗14 d。观察治疗前后2组神经功能缺损评分、日常生活活动能力（ADL ）与脑水肿体积变化。结果与治疗前相比，2组治疗后神经功能缺损评分明显降低，脑水肿体积缩小，ADL评分明显提高，且观察组较对照组改善更为明显。结论 GM 1联合依达拉奉治疗急性脑出血较单一使用依达拉奉效果更明显，可有效减少脑水肿体积，提高患者日常生活活动能力，降低致残率。
目的：觀察單唾液痠四己糖神經節苷脂鈉（GM1）聯閤依達拉奉在急性腦齣血治療中的應用效果。方法選取我院2009-01-2012-01收治的102例急性腦齣血患者，隨機分為對照組（n＝50）與觀察組（n＝52），對照組在常規治療基礎上加用依達拉奉註射液30 mg＋0.9％氯化鈉註射液100 mL靜滴，2次／d ，觀察組在對照組基礎上給予GM1100 mg＋0.9％氯化鈉註射液250 mL靜滴，1次／d ，2組均連續治療14 d。觀察治療前後2組神經功能缺損評分、日常生活活動能力（ADL ）與腦水腫體積變化。結果與治療前相比，2組治療後神經功能缺損評分明顯降低，腦水腫體積縮小，ADL評分明顯提高，且觀察組較對照組改善更為明顯。結論 GM 1聯閤依達拉奉治療急性腦齣血較單一使用依達拉奉效果更明顯，可有效減少腦水腫體積，提高患者日常生活活動能力，降低緻殘率。
목적：관찰단타액산사기당신경절감지납（GM1）연합의체랍봉재급성뇌출혈치료중적응용효과。방법선취아원2009-01-2012-01수치적102례급성뇌출혈환자，수궤분위대조조（n＝50）여관찰조（n＝52），대조조재상규치료기출상가용의체랍봉주사액30 mg＋0.9％록화납주사액100 mL정적，2차／d ，관찰조재대조조기출상급여GM1100 mg＋0.9％록화납주사액250 mL정적，1차／d ，2조균련속치료14 d。관찰치료전후2조신경공능결손평분、일상생활활동능력（ADL ）여뇌수종체적변화。결과여치료전상비，2조치료후신경공능결손평분명현강저，뇌수종체적축소，ADL평분명현제고，차관찰조교대조조개선경위명현。결론 GM 1연합의체랍봉치료급성뇌출혈교단일사용의체랍봉효과경명현，가유효감소뇌수종체적，제고환자일상생활활동능력，강저치잔솔。
Objective To observe the efficacy of monosialotetrahexosyl ganglioside sodium combined with edaravone in the treatment of acute cerebral hemorrhage .Methods From January 2009 to January 2012 ,102 cases of patients with acute cerebral hemorrhage admitted to our hospital were selected ,and randomly divided into control group (n=50)and observation group(n=52) .On the basis of conventional treatment ,control group was given edaravone (30 mg+0 .9% sodium chloride 100 mL ,intra-venous drip ,twice a day) .Observation group was given GM1 (100 mg+0 .9% sodium chloride injection 250 mL ,intravenous drip ,once a day) based on the control group .Patients in the two groups were treated for 14 days consecutively .The neural func-tion defect scoring ,activities of daily living (ADL ) and cerebral edema volume changes of the two groups before and after treat-ment were observed .Results After treatment ,the neural function defect scoring significantly lowered ,cerebral edema volume decreased ,ADL scale scores improved in the two groups ,which were more remarkable in observation group .Conclusion the clinical effect of GM 1 combined with edaravone in the treatment of acute cerebral hemorrhage is more obvious than that of edar-avone single used .It can effectively reduce cerebral edema volume and improve the activities of daily living ,and decrease disabili-ty rates .
