中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2014年
26期
43-45
,共3页
罗苹%项余华%汪军华%李有辉
囉蘋%項餘華%汪軍華%李有輝
라평%항여화%왕군화%리유휘
骨关节炎%C反应蛋白质%基质金属蛋白酶3%臭氧
骨關節炎%C反應蛋白質%基質金屬蛋白酶3%臭氧
골관절염%C반응단백질%기질금속단백매3%취양
Osteoarthritis%C-reactive protein%Matrix metalloproteinase-3%Ozone
目的 观察臭氧治疗对膝骨性关节炎患者关节滑液中高敏C反应蛋白(hs-CRP)和基质金属蛋白酶3(MMP-3)的影响,探讨其治疗骨性关节炎的作用机制.方法 将62例膝骨性关节炎患者按随机数字表法分为对照组和观察组,每组31例.对照组给予关节腔内注射玻璃酸钠治疗,观察组给予关节腔内注射医用臭氧治疗,每周1次,连续治疗5次为1个疗程.评价两组临床疗效,并检测治疗前后两组患者关节滑液中hs-CRP和MMP-3水平.结果 观察组总有效率为100.00％(3l/31),显著高于对照组的87.10％(27/31),差异有统计学意义(x2=4.28,P＜0.05).观察组治疗后关节滑液中hs-CRP和MMP-3水平分别为(6.68±2.15) mg/L、(69.84±16.97) μg/L,均明显低于对照组的(8.72 ± 2.39) mg/L、(85.43±19.52) μg/L,差异有统计学意义(t=3.53,3.36,P＜0.01).结论 臭氧治疗膝骨性关节炎疗效确切,其作用机制可能与其抑制炎性反应、降低关节滑液中MMP-3水平有关.
目的 觀察臭氧治療對膝骨性關節炎患者關節滑液中高敏C反應蛋白(hs-CRP)和基質金屬蛋白酶3(MMP-3)的影響,探討其治療骨性關節炎的作用機製.方法 將62例膝骨性關節炎患者按隨機數字錶法分為對照組和觀察組,每組31例.對照組給予關節腔內註射玻璃痠鈉治療,觀察組給予關節腔內註射醫用臭氧治療,每週1次,連續治療5次為1箇療程.評價兩組臨床療效,併檢測治療前後兩組患者關節滑液中hs-CRP和MMP-3水平.結果 觀察組總有效率為100.00％(3l/31),顯著高于對照組的87.10％(27/31),差異有統計學意義(x2=4.28,P＜0.05).觀察組治療後關節滑液中hs-CRP和MMP-3水平分彆為(6.68±2.15) mg/L、(69.84±16.97) μg/L,均明顯低于對照組的(8.72 ± 2.39) mg/L、(85.43±19.52) μg/L,差異有統計學意義(t=3.53,3.36,P＜0.01).結論 臭氧治療膝骨性關節炎療效確切,其作用機製可能與其抑製炎性反應、降低關節滑液中MMP-3水平有關.
목적 관찰취양치료대슬골성관절염환자관절활액중고민C반응단백(hs-CRP)화기질금속단백매3(MMP-3)적영향,탐토기치료골성관절염적작용궤제.방법 장62례슬골성관절염환자안수궤수자표법분위대조조화관찰조,매조31례.대조조급여관절강내주사파리산납치료,관찰조급여관절강내주사의용취양치료,매주1차,련속치료5차위1개료정.평개량조림상료효,병검측치료전후량조환자관절활액중hs-CRP화MMP-3수평.결과 관찰조총유효솔위100.00％(3l/31),현저고우대조조적87.10％(27/31),차이유통계학의의(x2=4.28,P＜0.05).관찰조치료후관절활액중hs-CRP화MMP-3수평분별위(6.68±2.15) mg/L、(69.84±16.97) μg/L,균명현저우대조조적(8.72 ± 2.39) mg/L、(85.43±19.52) μg/L,차이유통계학의의(t=3.53,3.36,P＜0.01).결론 취양치료슬골성관절염료효학절,기작용궤제가능여기억제염성반응、강저관절활액중MMP-3수평유관.
Objective To explore the influence of ozone therapy on high-sensitivity C-reactive protein (hs-CRP) and matrix metalloproteinases-3 (MMP-3) in synovial fluid of patients with knee osteoarthritis,and to investigate the possible mechanism.Methods Sixty-two patients with knee osteoarthritis were divided into observation group and control group by random digits table method with 31 cases each.The patients of observation group were treated with ozone,while the patients of control group were treated with hyaluronic acid once a week for 5 weeks.The efficacy was evaluated and the level of hs-CRP and MMP-3 in synovial fluid were detected before and after treatment.Results The total effective rate in observation group was 100.00％ (31/31),significantly higher than that in control group [87.10％ (27/31)],and there was significant difference (x2 =4.28,P ＜ 0.05).After treatment,the level of hs-CRP and MMP-3 in observation group was (6.68 ±2.15) mg/L,(69.84 ± 16.97) μ g/L,significantly lower than that in control group [(8.72 ± 2.39) mg/L,(85.43 ± 19.52) tμ g/L],and there was significant difference (t =3.53,3.36,P ＜ 0.01).Conclusion There is significant effect of ozone therapy of patients with knee osteoarthritis,its mechanism may be reducing the level of MMP-3 and inhibiting inflammatory reaction.
