CAJ | 학술논문

足细胞是位于肾小球基底膜外侧的高度分化的细胞，有高度的结构和功能特异性，在维持肾小球滤过膜的结构和功能上起着重要作用。研究发现足细胞损伤是介导肾小球疾病进展的关键因素，以足细胞损伤为靶点的治疗现已成为慢性肾脏病治疗的新手段。目前足细胞损伤机制的研究是肾脏疾病领域的研究热点，足细胞损伤的信号通路为人们深入探索其致病机制提供了重要线索，对信号通路中关键分子的干预可能为治疗足细胞病提供新的方向。本文主要介绍无翅型MMTV整合位点家族成员蛋白（Wnt）/β-连环蛋白（β-catenin）、缺刻蛋白（Notch）信号通路，足细胞骨架调控信号通路，转化生长因子-β（TGF-β）/骨形成蛋白（BMP-7）通路及自噬通路在足细胞损伤中的最新进展。
족세포시위우신소구기저막외측적고도분화적세포，유고도적결구화공능특이성，재유지신소구려과막적결구화공능상기착중요작용。연구발현족세포손상시개도신소구질병진전적관건인소，이족세포손상위파점적치료현이성위만성신장병치료적신수단。목전족세포손상궤제적연구시신장질병영역적연구열점，족세포손상적신호통로위인문심입탐색기치병궤제제공료중요선색，대신호통로중관건분자적간예가능위치료족세포병제공신적방향。본문주요개소무시형MMTV정합위점가족성원단백（Wnt）/β-련배단백（β-catenin）、결각단백（Notch）신호통로，족세포골가조공신호통로，전화생장인자-β（TGF-β）/골형성단백（BMP-7）통로급자서통로재족세포손상중적최신진전。
Podocytes are terminally differentiated cells located on the outer surface of the glomerular basement membrane with specific architecture and function,and play a key role in maintaining the structure and function of the glomerular filtration barrier.Accumulating evidence suggests that podocytes play a pivotal role in the pathogenesis and progression of glomerular disease and will become an efficient target for the novel therapy of chronic kidney disease.Many studies are now focused on the mechanisms of podocyte injury,the signaling pathways of which provide crucial clues to the pathogenetic mechanism.Interventions on the key factors in the signaling pathways will be potential therapies for podocytopathy.In this review,we highlight both the classic and latest signaling pathways within podocyte injury including Wnt/β-catenin,Notch signaling pathway,podocyte cytoskeleton regulatory signaling pathway,transforming growth factor-β(TGF-β)/bone morphogenetic protein 7 (BMP-7)signaling pathway,and autophagy pathway.