CAJ | 학술논문

复发性流产（recurrent spontaneous abortion，RSA）是妊娠中常见的临床并发症之一，也是一直困扰医生和患者的一个难题，RSA不仅对患者的身体健康造成了危害，还严重影响了他们的家庭幸福。RSA是一种多因素疾病，病因复杂，其发病受遗传因素，环境因素及生活方式（如饮酒，咖啡及吸烟）等多方面的共同影响。近年来，有报道认为氧化应激（oxidative stress，OS）是RSA发病的高危因素之一，其中谷胱甘肽S-转移酶（glutathione S-transferases，GSTs）是体内氧化/抗氧化系统的重要成员，在体内活性氧产物（reactive oxygen species，ROS）的代谢中发挥重要作用。若GSTs的表达或功能出现异常，将会导致胚胎及胎盘暴露于内源性及外源性有害物质的损伤而导致流产。现将 GST基因与 RSA 发病的相关性研究做一综述。
복발성유산（recurrent spontaneous abortion，RSA）시임신중상견적림상병발증지일，야시일직곤우의생화환자적일개난제，RSA불부대환자적신체건강조성료위해，환엄중영향료타문적가정행복。RSA시일충다인소질병，병인복잡，기발병수유전인소，배경인소급생활방식（여음주，가배급흡연）등다방면적공동영향。근년래，유보도인위양화응격（oxidative stress，OS）시RSA발병적고위인소지일，기중곡광감태S-전이매（glutathione S-transferases，GSTs）시체내양화/항양화계통적중요성원，재체내활성양산물（reactive oxygen species，ROS）적대사중발휘중요작용。약GSTs적표체혹공능출현이상，장회도치배태급태반폭로우내원성급외원성유해물질적손상이도치유산。현장 GST기인여 RSA 발병적상관성연구주일종술。
Recurrent spontaneous abortion (RSA) is a common and frustrating pregnancy complication. RSA not only has an adverse effect on the patients' health, but also brings the patients' families great pain. RSA is a multifactor disorder. Multiple factors including genetic factors, environment, habits and customs, such as cigarette smoking, the consumption of alcohol and coffee, have effect on the development of RSA. Accumulating studies have suggested that oxidative stress (OS) may be one of the risk factors of RSA in recent years. In the oxidant/antioxidant system in vivo, glutathione S-transferases (GSTs) play an important role in the detoxification of reactive oxygen species (ROS). The genetic variant of the GST gene could lead to the abnormal expression and function of GSTs, as a result, increased exposure of the conceptus to the exo- and endogenous toxins might contribute to the development of RSA. In this review, we will focus on the role of GST gene in the development of RSA.