CAJ | 학술논문

IGF-1是生长激素诱导代谢与合成作用的内分泌介质，也可通过旁分泌与自分泌方式产生并作用于细胞，通过多种信号转导通路调节细胞生长、分化、转化和凋亡，如 IGF-1异常增高或调节过程失调将促使细胞增殖失控进而导致恶变。IGF-1在神经系统中具有促进神经系统发育、抗凋亡等作用，另一方面则与胶质瘤、脑膜瘤、垂体瘤的发生发展有着密切的联系，其与颅内肿瘤级别关系及作为基因治疗的新靶点逐渐得到更多的研究和关注。
IGF-1시생장격소유도대사여합성작용적내분비개질，야가통과방분비여자분비방식산생병작용우세포，통과다충신호전도통로조절세포생장、분화、전화화조망，여 IGF-1이상증고혹조절과정실조장촉사세포증식실공진이도치악변。IGF-1재신경계통중구유촉진신경계통발육、항조망등작용，령일방면칙여효질류、뇌막류、수체류적발생발전유착밀절적련계，기여로내종류급별관계급작위기인치료적신파점축점득도경다적연구화관주。
IGF-1, as a kind of endocrine medium, is associated with the effect of GH-induced metabolism and synthesis, it can be produced by cells through paracrine and autocrine manner, by a variety of signal transduction pathways that regulate cell growth, differentiation, transformation and apoptosis, such as IGF-1 abnormal increase or adjustment process will lead to uncontrolled cell proliferation disorders leading to malignant transformation. IGF-1 can play a role in anti-apoptosis and promoting the development of nervous system, on the other hand, IGF-1 has a close relationship with origination and development of gliomas, meningiomas and pituitary adenomas. Its level of relations with intracranial tumors and as new target for gene therapy research and gradually get more attention.