CAJ | 학술논문

血清胃蛋白酶原（sPG）可以确切地反映胃蛋白酶的分泌以及胃黏膜状态和功能情况。sPG与胃部疾病的发生发展相关，被誉为胃黏膜病变的“血清学活检”，且检测sPG具有简便、快捷、重复性好、非侵入性、便于动态监测等优点；确定合适的sPG检测临界值，更有助于更灵敏地诊断胃部病变。本文就PG的生物特性，影响因素及与胃疾病的关系几个方面予以综述。
혈청위단백매원（sPG）가이학절지반영위단백매적분비이급위점막상태화공능정황。sPG여위부질병적발생발전상관，피예위위점막병변적“혈청학활검”，차검측sPG구유간편、쾌첩、중복성호、비침입성、편우동태감측등우점；학정합괄적sPG검측림계치，경유조우경령민지진단위부병변。본문취PG적생물특성，영향인소급여위질병적관계궤개방면여이종술。
Serum pepsinogen (sPG) can exactly reflect the pepsin secretion and gastric mucosal status and functions. As the level of serum pepsinogen relates to the lesions occurred in gastric mucosa, sPG is known as the serological biopsy of gastric mucosal lesions. And the detection of sPG is simple, fast, reproducible, non-intrusive and convenient of dynamic monitoring etc. Determination of the critical value of sPG contributes to more sensitive diagnosis of gastric disease. In this review, we overview mainly from the following several aspects:the biological characteristics of sPG, the influencing factors of sPG, and the relationship between sPG and gastric diseases.