CAJ | 학술논문

长链非编码RNA（lncRNA）是一系列广泛转录自人及其他哺乳动物基因组的长度超过200 nt的核苷酸片段，通常没有蛋白编码功能，一度被认为是基因组的转录“噪音”。近年来一些 lncRNA 被发现具有多种生物学功能，成为分子生物学领域研究的热点。已经在多种肿瘤中发现有lncRNA的异常表达，并且异常表达的 lncRNA 和肿瘤的复发、转移及预后有关。本文中将探讨近期发现的与消化系统肿瘤相关的lncRNA，部分着重于具有促癌作用的lncRNA，以期为消化系统肿瘤的诊断、预后及分子治疗提供线索。
장련비편마RNA（lncRNA）시일계렬엄범전록자인급기타포유동물기인조적장도초과200 nt적핵감산편단，통상몰유단백편마공능，일도피인위시기인조적전록“조음”。근년래일사 lncRNA 피발현구유다충생물학공능，성위분자생물학영역연구적열점。이경재다충종류중발현유lncRNA적이상표체，병차이상표체적 lncRNA 화종류적복발、전이급예후유관。본문중장탐토근기발현적여소화계통종류상관적lncRNA，부분착중우구유촉암작용적lncRNA，이기위소화계통종류적진단、예후급분자치료제공선색。
Long non-coding RNAs (lncRNAs) are defined as transcripts longer than 200 nt with little or no protein-coding capacity generally transcribed in the human and other mammalian genome. Early research proposed that lncRNAs may simply represent transcriptional noise. Recent studys demonstrate that they are related to a wide range of biological functions, thus lncRNA become the rising new star of RNA research. Lots of lncRNAs are dysregulated in different kinds of cancer, and the expression levels of certain lncRNAs are associated with recurrence, metastasis, and prognosis of cancer. In this review, we focus on recent lncRNAs in the digestive system cancer, particularly on the lncRNAs as novel drivers of tumorigenesis, to provide new insights into the diagnosis and treatment of digestive system cancer in clinics.