中华临床医师杂志(电子版)
中華臨床醫師雜誌(電子版)
중화림상의사잡지(전자판)
CHINESE JOURNAL OF CLINICIANS(ELECTRONIC VERSION)
2013年
23期
10580-10583
,共4页
干燥综合征%发病年龄%临床分析
榦燥綜閤徵%髮病年齡%臨床分析
간조종합정%발병년령%림상분석
Sjogren's syndrome%Age of onset%Clinical analysis
目的:探讨不同年龄段发病的原发性干燥综合征(pSS)的临床特点。方法回顾性分析2005年7月至2012年1月在广西医科大学第一附属医院住院诊治的pSS患者227例,入选病例均符合2002年pSS国际分类(诊断)标准并排除合并其他结缔组织病。将入选病例按发病年龄不同分为青年组(≤40岁)和中老年组(>40岁),对两组pSS患者的临床资料进行统计分析。结果(1)227例pSS患者中女205例(90.3%)、男22例(9.7%),男∶女为1∶9.32,青年组73例(32.2%),中老年组154例(67.8%),两组发病人数之比约为1∶2。(2)pSS常见首发症状居前三位者分别为口眼干、关节肿痛、猖獗龋齿。青年组与中老年组首发症状的比较,口眼干(17.8%vs.34.4%,χ2=6.624,P=0.010)、猖獗龋齿(4.1%vs.18.8%,χ2=8.863,P=0.003)、血小板减少性紫癜(13.7%vs.2.6%,χ2=8.715,P=0.003)均有统计学差异。(3)89.4%的pSS患者合并系统损害,主要累及血液系统(60.4%)、肾(30.4%)。(4)pSS系统中肺损害与临床实验指标的相关分析:肺受累与 IgG、Glo 升高关系密切(P<0.01)。结论(1)青年组与中老年组发病人数比约为1∶2。(2)不同年龄 pSS 的首发症状不一。中老年组口眼干、猖獗龋齿较青年组明显增加,血小板减少性紫癜多见于青年组。(3)pSS 合并系统受累的发生率高(89.4%)。中老年组出现肾小球肾炎、肾功能不全较多见,青年组发生血小板减少较中老年组明显增加。(4)pSS合并肺损伤与IgG、Glo升高关系密切。
目的:探討不同年齡段髮病的原髮性榦燥綜閤徵(pSS)的臨床特點。方法迴顧性分析2005年7月至2012年1月在廣西醫科大學第一附屬醫院住院診治的pSS患者227例,入選病例均符閤2002年pSS國際分類(診斷)標準併排除閤併其他結締組織病。將入選病例按髮病年齡不同分為青年組(≤40歲)和中老年組(>40歲),對兩組pSS患者的臨床資料進行統計分析。結果(1)227例pSS患者中女205例(90.3%)、男22例(9.7%),男∶女為1∶9.32,青年組73例(32.2%),中老年組154例(67.8%),兩組髮病人數之比約為1∶2。(2)pSS常見首髮癥狀居前三位者分彆為口眼榦、關節腫痛、猖獗齲齒。青年組與中老年組首髮癥狀的比較,口眼榦(17.8%vs.34.4%,χ2=6.624,P=0.010)、猖獗齲齒(4.1%vs.18.8%,χ2=8.863,P=0.003)、血小闆減少性紫癜(13.7%vs.2.6%,χ2=8.715,P=0.003)均有統計學差異。(3)89.4%的pSS患者閤併繫統損害,主要纍及血液繫統(60.4%)、腎(30.4%)。(4)pSS繫統中肺損害與臨床實驗指標的相關分析:肺受纍與 IgG、Glo 升高關繫密切(P<0.01)。結論(1)青年組與中老年組髮病人數比約為1∶2。(2)不同年齡 pSS 的首髮癥狀不一。中老年組口眼榦、猖獗齲齒較青年組明顯增加,血小闆減少性紫癜多見于青年組。(3)pSS 閤併繫統受纍的髮生率高(89.4%)。中老年組齣現腎小毬腎炎、腎功能不全較多見,青年組髮生血小闆減少較中老年組明顯增加。(4)pSS閤併肺損傷與IgG、Glo升高關繫密切。
목적:탐토불동년령단발병적원발성간조종합정(pSS)적림상특점。방법회고성분석2005년7월지2012년1월재엄서의과대학제일부속의원주원진치적pSS환자227례,입선병례균부합2002년pSS국제분류(진단)표준병배제합병기타결체조직병。장입선병례안발병년령불동분위청년조(≤40세)화중노년조(>40세),대량조pSS환자적림상자료진행통계분석。결과(1)227례pSS환자중녀205례(90.3%)、남22례(9.7%),남∶녀위1∶9.32,청년조73례(32.2%),중노년조154례(67.8%),량조발병인수지비약위1∶2。(2)pSS상견수발증상거전삼위자분별위구안간、관절종통、창궐우치。청년조여중노년조수발증상적비교,구안간(17.8%vs.34.4%,χ2=6.624,P=0.010)、창궐우치(4.1%vs.18.8%,χ2=8.863,P=0.003)、혈소판감소성자전(13.7%vs.2.6%,χ2=8.715,P=0.003)균유통계학차이。(3)89.4%적pSS환자합병계통손해,주요루급혈액계통(60.4%)、신(30.4%)。(4)pSS계통중폐손해여림상실험지표적상관분석:폐수루여 IgG、Glo 승고관계밀절(P<0.01)。결론(1)청년조여중노년조발병인수비약위1∶2。(2)불동년령 pSS 적수발증상불일。중노년조구안간、창궐우치교청년조명현증가,혈소판감소성자전다견우청년조。(3)pSS 합병계통수루적발생솔고(89.4%)。중노년조출현신소구신염、신공능불전교다견,청년조발생혈소판감소교중노년조명현증가。(4)pSS합병폐손상여IgG、Glo승고관계밀절。
Objective To study the differences in clinical characteristics of primary Sj?gren's syndrome (pSS) in a different onset age. Methods Two hundred and twenty seven patients from the first affiliated hospital of Guangxi Medical University between July 2005 and January 2012 were studied retrospectively. These patients were divided into the youth group (onset younger than 40) and the middle-old age group (onset older than 40). Results (1)The study consisted of 205 (90.3%) female and 22 (9.7%) male patients (female∶male 9.32∶1). 73 (32.2%) patients of the disease onset occurred before the age of 40 years and 154 (67.8%) occurred after the age of 40 years the ratio between the youth group (32.2%) and the middle-old age group (67.8%) was 1∶2. (2) The first three ones more common initial symptoms were dry mouth and dry eyes , decayed tooth and joint pain . in addition, the former two initial symptoms were often found in the middle-old age group patients, significantly higher than the youth group (P≤0.01), however lower in thrombocytopenic purpura (P=0.003). (3) Systemic involvement occurred in (89.4%) patients, including blood system involvement(60.4%), renal involvement (30.4%). (4) The main relevance factor of lung involvement were IgG and Glo (P<0.01). Conclusion (1) The rate of onset of the youth group and the middle-old age group in pSS was about 1∶2. (2) The typical initial symptom of the middle-old age group were dry mouth and dry eyes and decayed tooth, while thrombocytopenic purpura was more common in the youth group. (3)Systemic involvement occurred in 89.4%patients. Compared with the youth group, higher prevalence of interstitial lung disease, glomerulonephritis and renal insufficiency in the middle-old age group, while much lower incidence of thrombocytopenia than the youth group. (4)Lung involvement was closely related to the increase of IgG and Glo level in pSS.