中华临床医师杂志（电子版）
中華臨床醫師雜誌（電子版）
중화림상의사잡지（전자판）
CHINESE JOURNAL OF CLINICIANS(ELECTRONIC VERSION)
2013年
23期
10435-10438
,共4页
黄冠男%刁玉荃%姜相君
黃冠男%刁玉荃%薑相君
황관남%조옥전%강상군
MUC1基因%多态性,单核苷酸%胃肿瘤
MUC1基因%多態性,單覈苷痠%胃腫瘤
MUC1기인%다태성,단핵감산%위종류
MUC1 gene%Polymorphism,single nucleotide%Stomach neoplasms
目的：探讨 MUC1基因多态性与胃癌遗传易感性的关系。方法采用病例对照研究对150例胃癌患者（胃癌组）和150名健康查体正常者（对照组）的MUC1基因rs2070803单核苷酸多态性进行检测，并分析其与胃癌易感性之间的关系。结果 MUC1基因rs2070803位点3种基因型GG、GA、AA在胃癌病例组中频率分别为80.7%、16.0%和3.3%，而在对照组中分别为64.7%、32.0%和3.3%。与GG型比较，GA/AA型基因型者胃癌发生的危险性降低，OR值为0.439（0.259～0.742）。结论 MUC1基因rs2070803位点GG、GA基因型降低汉族人群的胃癌易感性。
目的：探討 MUC1基因多態性與胃癌遺傳易感性的關繫。方法採用病例對照研究對150例胃癌患者（胃癌組）和150名健康查體正常者（對照組）的MUC1基因rs2070803單覈苷痠多態性進行檢測，併分析其與胃癌易感性之間的關繫。結果 MUC1基因rs2070803位點3種基因型GG、GA、AA在胃癌病例組中頻率分彆為80.7%、16.0%和3.3%，而在對照組中分彆為64.7%、32.0%和3.3%。與GG型比較，GA/AA型基因型者胃癌髮生的危險性降低，OR值為0.439（0.259～0.742）。結論 MUC1基因rs2070803位點GG、GA基因型降低漢族人群的胃癌易感性。
목적：탐토 MUC1기인다태성여위암유전역감성적관계。방법채용병례대조연구대150례위암환자（위암조）화150명건강사체정상자（대조조）적MUC1기인rs2070803단핵감산다태성진행검측，병분석기여위암역감성지간적관계。결과 MUC1기인rs2070803위점3충기인형GG、GA、AA재위암병례조중빈솔분별위80.7%、16.0%화3.3%，이재대조조중분별위64.7%、32.0%화3.3%。여GG형비교，GA/AA형기인형자위암발생적위험성강저，OR치위0.439（0.259～0.742）。결론 MUC1기인rs2070803위점GG、GA기인형강저한족인군적위암역감성。
Objective To investigate the relationships between the rs2070803 polymorphism of the MUC1 gene and susceptibility to gastric cancer. Methods A case-control study was used to conducted to investigate whether the polymorphism rs2070803 in MUC1 might be associated with risk of gastric cancer in 150 incident cases with gastric cancer and 150 controls recruited in a Chinese population. Results The data showed that, In rs2070803, the frequency of GG genotype was 80.7%in gastric cancer patients and 64.7%in normal controls, GA genotype was associated with a decrease in risk to an adjusted OR of 0.393 (95%CI 0.225-0.685) and rs2070803 GA/AA to0.439(95% CI 0.259-0.742). Conclusion The rs2070803 in MUC1 gene are associated with reduced susceptibility to gastric cancer and may play a protective role in a Chinese population.
