广州化工
廣州化工
엄주화공
GUANGZHOU CHEMICAL INDUSTRY AND TECHNOLOGY
2013年
24期
66-67,94
,共3页
KTDA%肿瘤细胞%MTT法%抗肿瘤活性
KTDA%腫瘤細胞%MTT法%抗腫瘤活性
KTDA%종류세포%MTT법%항종류활성
KTDA%tumor cells%MTT assay%antitumor activity
3-羰基-甘遂-8，24-二烯-21-羧酸（ KTDA）对某些肿瘤细胞有抑制增殖作用，且曾浓度依赖性[1]。本文将KTDA进行胺化以及酯化得到7个KTDA衍生物，并采用MTT法评价了KTDA以及7个衍生物对SMMC-7721、 A549、 Eca-109、KB四种肿瘤细胞的体外抗肿瘤活性。衍生物中化合物2对SMMC-7721肿瘤细胞的IC50值比KTDA的IC50值低，化合物8对SMMC-7721、 Eca-109肿瘤细胞的IC50值比KTDA的IC50值低。
3-羰基-甘遂-8，24-二烯-21-羧痠（ KTDA）對某些腫瘤細胞有抑製增殖作用，且曾濃度依賴性[1]。本文將KTDA進行胺化以及酯化得到7箇KTDA衍生物，併採用MTT法評價瞭KTDA以及7箇衍生物對SMMC-7721、 A549、 Eca-109、KB四種腫瘤細胞的體外抗腫瘤活性。衍生物中化閤物2對SMMC-7721腫瘤細胞的IC50值比KTDA的IC50值低，化閤物8對SMMC-7721、 Eca-109腫瘤細胞的IC50值比KTDA的IC50值低。
3-탄기-감수-8，24-이희-21-최산（ KTDA）대모사종류세포유억제증식작용，차증농도의뢰성[1]。본문장KTDA진행알화이급지화득도7개KTDA연생물，병채용MTT법평개료KTDA이급7개연생물대SMMC-7721、 A549、 Eca-109、KB사충종류세포적체외항종류활성。연생물중화합물2대SMMC-7721종류세포적IC50치비KTDA적IC50치저，화합물8대SMMC-7721、 Eca-109종류세포적IC50치비KTDA적IC50치저。
3-keto-tirucall-8,24-dien-21-oic acid( KTDA) was demonstrated to inhibit some tumor cells in a concentration dependent manner.Seven KTDA derivatives were achieved through amination and esterification of KTDA, and their in-vivo antitumor activities were evaluated by MTT assay on four tumor cells of SMMC-7721, A549, Eca-109 and KB.Compared with KTDA, the antitumor activities against SMMC-7721 of compound 2 manifestly increased, while compound 8 displayed better antitumor activities than KTDA against SMMC-7721 and Eca-109.
