广州化工
廣州化工
엄주화공
GUANGZHOU CHEMICAL INDUSTRY AND TECHNOLOGY
2013年
24期
64-65
,共2页
盐酸氟哌噻吨%2-三氟甲基-9-噻吨酮%合成%抗精神病药
鹽痠氟哌噻噸%2-三氟甲基-9-噻噸酮%閤成%抗精神病藥
염산불고새둔%2-삼불갑기-9-새둔동%합성%항정신병약
flupenthixol dihydrochloride%2-trifluoromethylthioxanthen-9-one%synthesis%antipsychotic drug
对盐酸氟哌噻吨合成工艺进行了优化研究。以2-三氟甲基-9-噻吨酮为起始原料，与1-（2-苄氧乙基）-4-（3-氯丙基）哌嗪进行格式反应，经脱水生成10-[3-[4-（2-苄氧乙基）-1-哌嗪基]丙基-9-羟基-2-三氟甲基噻吨，然后脱保护反应得氟哌噻吨游离碱，成盐而得盐酸氟哌噻吨成品，容量分析法检测纯度高于99.4％，收率大于59.0％。
對鹽痠氟哌噻噸閤成工藝進行瞭優化研究。以2-三氟甲基-9-噻噸酮為起始原料，與1-（2-芐氧乙基）-4-（3-氯丙基）哌嗪進行格式反應，經脫水生成10-[3-[4-（2-芐氧乙基）-1-哌嗪基]丙基-9-羥基-2-三氟甲基噻噸，然後脫保護反應得氟哌噻噸遊離堿，成鹽而得鹽痠氟哌噻噸成品，容量分析法檢測純度高于99.4％，收率大于59.0％。
대염산불고새둔합성공예진행료우화연구。이2-삼불갑기-9-새둔동위기시원료，여1-（2-변양을기）-4-（3-록병기）고진진행격식반응，경탈수생성10-[3-[4-（2-변양을기）-1-고진기]병기-9-간기-2-삼불갑기새둔，연후탈보호반응득불고새둔유리감，성염이득염산불고새둔성품，용량분석법검측순도고우99.4％，수솔대우59.0％。
The synthetic process of flupenthixol dihydrochloride was studied.With 2-trifluoromethylthioxanthen-9-one as starting material through Grignard reaction, dehydrationg was prepared, which was subject to salt formation.The average yield of flupenthixol dihydrochloride was more than 59.0%with a purity of 99.4%.
