CAJ | 학술논문

目的：探讨乌司他丁联合山莨菪碱在创伤性肺损伤治疗过程中的临床治疗效果。方法：选取2011年1月-2013年1月本院收治的100例创伤性肺损伤患者的临床资料，按照随机数字表法将所有患者分为A、B、C、D组各25例。其中A组给予常规治疗，B组给予乌司他丁治疗，C组给予山莨菪碱治疗，D组给予乌司他丁联合山莨菪碱治疗。观察比较四组患者的氧合指数、机械通气时间，ICU住院时间、治疗后ARDS发生率、治疗有效率和血清TNF-α与IL-6水平。结果：D组机械通气时间、ICU住院时间均明显少于其他三组，四组治疗后的氧合指数均明显高于治疗前，且D组的氧合指数明显高于其他三组；D组治疗后的ARDS发生率明显低于A组，差异有统计学意义（P<0.05）。治疗前四组患者的血清TNF-α与IL-6水平比较差异均无统计学意义（P>0.05），治疗后四组患者的血清TNF-α与IL-6水平均明显低于治疗前，D组治疗后血清TNF-α与IL-6水平均明显低于其他三组，但D组治疗有效率88.0%明显高于其他三组，差异均有统计学意义（P<0.05）。结论：在创伤性肺损伤治疗、控制过程中，乌司他丁联合山莨菪碱的临床治疗效果显著，多药合用有效发挥药物协同作用，有效降低患者炎性因子释放，降低患者ICU住院时间与病死率，值得进一步研究推广。
목적：탐토오사타정연합산랑탕감재창상성폐손상치료과정중적림상치료효과。방법：선취2011년1월-2013년1월본원수치적100례창상성폐손상환자적림상자료，안조수궤수자표법장소유환자분위A、B、C、D조각25례。기중A조급여상규치료，B조급여오사타정치료，C조급여산랑탕감치료，D조급여오사타정연합산랑탕감치료。관찰비교사조환자적양합지수、궤계통기시간，ICU주원시간、치료후ARDS발생솔、치료유효솔화혈청TNF-α여IL-6수평。결과：D조궤계통기시간、ICU주원시간균명현소우기타삼조，사조치료후적양합지수균명현고우치료전，차D조적양합지수명현고우기타삼조；D조치료후적ARDS발생솔명현저우A조，차이유통계학의의（P<0.05）。치료전사조환자적혈청TNF-α여IL-6수평비교차이균무통계학의의（P>0.05），치료후사조환자적혈청TNF-α여IL-6수평균명현저우치료전，D조치료후혈청TNF-α여IL-6수평균명현저우기타삼조，단D조치료유효솔88.0%명현고우기타삼조，차이균유통계학의의（P<0.05）。결론：재창상성폐손상치료、공제과정중，오사타정연합산랑탕감적림상치료효과현저，다약합용유효발휘약물협동작용，유효강저환자염성인자석방，강저환자ICU주원시간여병사솔，치득진일보연구추엄。
Objective:To investigate the efficacy of Ulinastatin combined with Anisodamine in the treatment of traumatic lung injury.Method:The clinical data of 100 patients with traumatic lung injury in our hospital from January 2011 to January 2013 were selected,they were randomly divided into the group A,group B,group C and group D,25 cases in each group.The group A was given conventional therapy,the group B was treated with Ulinastatin,the group C was treated with Anisodamine,the group C wa treated with Ulinastatin combined with Anisodamine.Oxygenation index, duration of mechanical ventilation,ICU stay,the incidence of ARDS after treatment,the effective rate of treatment and serum TNF-α and IL-6 levels of four groups were observed and compared.Result:The duration of mechanical ventilation and ICU stay of the group D were significantly less than the other three groups,oxygenation index after treatment of the four groups were significantly higher than that before treatment,and oxygenation index of the group D was significantly higher than the other three groups;after treatment,the incidence of ARDS in group D was significantly lower than group A,the difference was statistically significant(P<0.05).There were no significant differences among four groups in serum TNF-α and IL-6 before treatment.After treatment,serum TNF-α and IL-6 of the four groups were significantly lower than before treatment,after treatment in group D,serum TNF-α and IL-6 levels were significantly lower than the other three groups,but the treatment efficiency of the group D (88.0%) was significantly higher than the other three groups, the differences were statistically significant(P<0.05).Conclusion:In the treatment and control process of traumatic acute lung injury,the clinical therapeutic effect of Ulinastatin combined with Anisodamine is significantly,many drugs exert synergistic effect,effectively reduce the release of inflammatory factors,reduce hospitalization time and mortality rate,worthy of further research and promotion.