上海医药
上海醫藥
상해의약
SHANGHAI MEDICAL & PHARMACEUTICAL JOURNAL
2014年
5期
51-54
,共4页
三唑类化合物%铜催化剂%合成%抗肿瘤活性
三唑類化閤物%銅催化劑%閤成%抗腫瘤活性
삼서류화합물%동최화제%합성%항종류활성
triazoles%Cu catalyst%synthesis%antitumor activity
以多孔铜为催化剂，通过卤代烃与端位炔烃及叠氮化钠Click反应，一锅法合成了6个1,4-取代的1,2,3-三唑化合物，其结构经1H NMR，13C NMR，IR和HR-MS表征。采用MTT法初步研究该类化合物对肿瘤细胞株的增殖抑制活性，结果表明化合物3e和3f具有一定的抗肿瘤活性，但均低于顺铂。
以多孔銅為催化劑，通過滷代烴與耑位炔烴及疊氮化鈉Click反應，一鍋法閤成瞭6箇1,4-取代的1,2,3-三唑化閤物，其結構經1H NMR，13C NMR，IR和HR-MS錶徵。採用MTT法初步研究該類化閤物對腫瘤細胞株的增殖抑製活性，結果錶明化閤物3e和3f具有一定的抗腫瘤活性，但均低于順鉑。
이다공동위최화제，통과서대경여단위결경급첩담화납Click반응，일과법합성료6개1,4-취대적1,2,3-삼서화합물，기결구경1H NMR，13C NMR，IR화HR-MS표정。채용MTT법초보연구해류화합물대종류세포주적증식억제활성，결과표명화합물3e화3f구유일정적항종류활성，단균저우순박。
1,2,3-Triazoles were synthesized using porous Cu as a catalyst via one-pot multi component reaction from alkynes, alkyl halides, and sodium azide. The structures were characterized by NMR, IR and HR-MS. Antitumor activities against cell line MCF-7, A549 and HL-60 were tested by MTT method. The results shown that compound 3e and 3f possessed certain antitumor activity, however, their activity was weaker than cis-dichlorodiamineplatinum(II).
