上海医药
上海醫藥
상해의약
SHANGHAI MEDICAL & PHARMACEUTICAL JOURNAL
2014年
5期
35-38
,共4页
药物性肝损伤%药物不良反应%合理用药
藥物性肝損傷%藥物不良反應%閤理用藥
약물성간손상%약물불량반응%합리용약
drug-induced liver injury%adverse drug reactions%rational drug use
目的：探讨各类药物导致药物性肝损害的规律和特点。方法：对2011-2013年上海市药品不良反应监测数据库内163例严重药物性肝损害报告进行分析。结果：药物性肝损害涉及的怀疑药品品种繁多，抗感染药物、抗肿瘤药、心血管药物较易引起药物性肝损害。65岁及以上年龄段发生不良反应的比例明显高于其他年龄段；合并用药将增加药物性肝损害的发生率。结论：应重视药品不良反应监测，合理用药，预防药物性肝损害发生。
目的：探討各類藥物導緻藥物性肝損害的規律和特點。方法：對2011-2013年上海市藥品不良反應鑑測數據庫內163例嚴重藥物性肝損害報告進行分析。結果：藥物性肝損害涉及的懷疑藥品品種繁多，抗感染藥物、抗腫瘤藥、心血管藥物較易引起藥物性肝損害。65歲及以上年齡段髮生不良反應的比例明顯高于其他年齡段；閤併用藥將增加藥物性肝損害的髮生率。結論：應重視藥品不良反應鑑測，閤理用藥，預防藥物性肝損害髮生。
목적：탐토각류약물도치약물성간손해적규률화특점。방법：대2011-2013년상해시약품불량반응감측수거고내163례엄중약물성간손해보고진행분석。결과：약물성간손해섭급적부의약품품충번다，항감염약물、항종류약、심혈관약물교역인기약물성간손해。65세급이상년령단발생불량반응적비례명현고우기타년령단；합병용약장증가약물성간손해적발생솔。결론：응중시약품불량반응감측，합리용약，예방약물성간손해발생。
Objective:To investigate the rule and characteristics of drug-induced liver injury (DILI). Methods:One hundred and sixty-three cases of DILI in Adverse Drug Reaction Monitoring database of Shanghai during 2011-2013 were analyzed. Results:DILI can be caused by many kinds of drugs such as anti-infective, anti-neoplastic and cardiovascular drugs. The incidence of adverse drug reactions in the people aged 65 and over is much higher than that of other age groups. Drug combination will increase the incidence of DILI. Conclusion:Great attention should be paid to the monitoring of adverse drug reaction and the rational drug use so as to prevent the occurrence of DILI.
