CAJ | 학술논문

目的：观察华法林假日疗法对心房颤动患者抗凝治疗的疗效及安全性。方法：将江苏省镇江市中医院2009年1月-2013年9月间收治的38例心房颤动患者随机分为华法林常规治疗组(对照组，n=20)和华法林假日疗法治疗组(观察组，n=18)，观察两组患者为期12个月的不良反应发生情况。结果：观察组患者治疗后的脑血栓等栓塞事件的发生率与对照组患者间无显著差异(5.6%：5%，P>0.05)。观察组患者治疗后出血发生率低于对照组患者(5.6%：20%，P＜0.05)，对照组由于未监测INR发生1例出血性死亡事件。结论：观察组患者栓塞风险未增加，出血风险发生率较低，价格便宜且不需要频繁监测INR，值得临床进一步观察使用。
목적：관찰화법림가일요법대심방전동환자항응치료적료효급안전성。방법：장강소성진강시중의원2009년1월-2013년9월간수치적38례심방전동환자수궤분위화법림상규치료조(대조조，n=20)화화법림가일요법치료조(관찰조，n=18)，관찰량조환자위기12개월적불량반응발생정황。결과：관찰조환자치료후적뇌혈전등전새사건적발생솔여대조조환자간무현저차이(5.6%：5%，P>0.05)。관찰조환자치료후출혈발생솔저우대조조환자(5.6%：20%，P＜0.05)，대조조유우미감측INR발생1례출혈성사망사건。결론：관찰조환자전새풍험미증가，출혈풍험발생솔교저，개격편의차불수요빈번감측INR，치득림상진일보관찰사용。
Objective:To observe the efifcacy and safety of warfarin holiday-therapy on the anticoagulation in patients with atrial ifbrillation (AF). Methods:Thirty-eight cases of patients with AF were randomly divided into two groups, a control group (conventional treatment of warfarin, n=20) and an observation group (warfarin holiday-therapy, n=18), to observe the adverse reactions in two groups during 12 months. Results:There was no signiifcant difference in the incidence rate of embolism events such as cerebral thrombosis between two groups (5.6% vs 5%, P>0.05), however, the incidence rate of bleeding was lower in the observation group than in the control group (5.6%vs 20%, P<0.05). One case of hemorrhagic death occurred in the control group due to the absence of the monitoring of INR. Conclusion:Warfarin holiday-therapy is worthy of further clinical observation due to no risk of embolism increase, lower bleeding risk , inexpensive costs and no need of frequent monitoring and determination of INR.