中国循证心血管医学杂志
中國循證心血管醫學雜誌
중국순증심혈관의학잡지
CHINESE JOURNAL OF EVIDENCE-BASES CARDIOVASCULAR MEDICINE
2014年
1期
68-70
,共3页
基质金属蛋白酶-1%肥厚型心肌病%流出道梗阻
基質金屬蛋白酶-1%肥厚型心肌病%流齣道梗阻
기질금속단백매-1%비후형심기병%류출도경조
Matrix metalloproteinase-1%Hypertrophic cardiomyopathy%Outflow tract obstruction
目的：探讨肥厚型心肌病（HCM）患者血浆基质金属蛋白酶-1（MMP-1）水平与左心室流出道梗阻的关系。方法纳入肥厚型心肌病患者72例，以基质金属蛋白酶-1（MMP-1）平均水平5.13 ng/ml为界将患者分为高MMP-1组（n=34）和低MMP-1组（n=38），分析两组患者性别、年龄、超声影像学等相关指标差异及与MMP-1相关的指标，同时比较梗阻性HCM与非梗阻性HCM患者的MMP-1水平差异。结果与低MMP-1组比较，高MMP-1组患者在年龄、氨基末端脑钠肽前体（NT-proBNP）、左心室流出道最大压差（LVOTPG）、左心室射血分数（LVEF）、左室后壁宽度（LVPWD）五项指标上存在统计学差异（P＜0.05）。NT-proBNP与MMP-1呈正相关（r=0.521，P=0.025），LVOTPG与MMP-1呈正相关（r=0.596，P=0.018)，LVEF与MMP-1呈负相关（r=-0.471，P=0.031），LVPWD与MMP-1无显著相关性。梗阻性HCM患者较非梗阻性HCM患者的MMP-1水平显著升高，差异有统计学意义（P＜0.05）。结论MMP-1与NT-proBNP、LVOTPG、LVEF有相关性，在肥厚型心肌病患者左心室流出道梗阻的判断中有一定的价值。
目的：探討肥厚型心肌病（HCM）患者血漿基質金屬蛋白酶-1（MMP-1）水平與左心室流齣道梗阻的關繫。方法納入肥厚型心肌病患者72例，以基質金屬蛋白酶-1（MMP-1）平均水平5.13 ng/ml為界將患者分為高MMP-1組（n=34）和低MMP-1組（n=38），分析兩組患者性彆、年齡、超聲影像學等相關指標差異及與MMP-1相關的指標，同時比較梗阻性HCM與非梗阻性HCM患者的MMP-1水平差異。結果與低MMP-1組比較，高MMP-1組患者在年齡、氨基末耑腦鈉肽前體（NT-proBNP）、左心室流齣道最大壓差（LVOTPG）、左心室射血分數（LVEF）、左室後壁寬度（LVPWD）五項指標上存在統計學差異（P＜0.05）。NT-proBNP與MMP-1呈正相關（r=0.521，P=0.025），LVOTPG與MMP-1呈正相關（r=0.596，P=0.018)，LVEF與MMP-1呈負相關（r=-0.471，P=0.031），LVPWD與MMP-1無顯著相關性。梗阻性HCM患者較非梗阻性HCM患者的MMP-1水平顯著升高，差異有統計學意義（P＜0.05）。結論MMP-1與NT-proBNP、LVOTPG、LVEF有相關性，在肥厚型心肌病患者左心室流齣道梗阻的判斷中有一定的價值。
목적：탐토비후형심기병（HCM）환자혈장기질금속단백매-1（MMP-1）수평여좌심실류출도경조적관계。방법납입비후형심기병환자72례，이기질금속단백매-1（MMP-1）평균수평5.13 ng/ml위계장환자분위고MMP-1조（n=34）화저MMP-1조（n=38），분석량조환자성별、년령、초성영상학등상관지표차이급여MMP-1상관적지표，동시비교경조성HCM여비경조성HCM환자적MMP-1수평차이。결과여저MMP-1조비교，고MMP-1조환자재년령、안기말단뇌납태전체（NT-proBNP）、좌심실류출도최대압차（LVOTPG）、좌심실사혈분수（LVEF）、좌실후벽관도（LVPWD）오항지표상존재통계학차이（P＜0.05）。NT-proBNP여MMP-1정정상관（r=0.521，P=0.025），LVOTPG여MMP-1정정상관（r=0.596，P=0.018)，LVEF여MMP-1정부상관（r=-0.471，P=0.031），LVPWD여MMP-1무현저상관성。경조성HCM환자교비경조성HCM환자적MMP-1수평현저승고，차이유통계학의의（P＜0.05）。결론MMP-1여NT-proBNP、LVOTPG、LVEF유상관성，재비후형심기병환자좌심실류출도경조적판단중유일정적개치。
Objective To discuss the relationship between level of plasma matrix metalloproteinase-1 (MMP-1) and left ventricular outflow tract obstruction in patients with hypertrophic cardiomyopathy (HCM). Methods HCM patients (n=72) were divided into high MMP-1 group (n=34) and low MMP-1 group (n=38) taken average level of MMP-1 (5.13 ng/mL) as a bound. The difference in indexes of sex, age and ultrasound image, and correlation between these indexes and MMP-1 were analyzed. The level of MMP-1 was compared between the patients with obstructive HCM and those with non-obstructive HCM. Results The comparison between low MMP-1 group and high MMP-1 group showed that there were statistical differences in age, NT-proBNP, LVOTPG, LVEF and LVPWD (P<0.05). NT-proBNP was positively correlated to MMP-1 (r=0.521, P=0.025), LVOTPG was positively correlated to MMP-1 (r=0.596, P=0.018), LVEF was negatively correlated to MMP-1 (r=-0.471, P=0.031), and LVPWD was not correlated to MMP-1. The relation between age and MMP-1 showed a nonlinear correlation. The level of MMP-1 increased significantly in the patients with obstructive HCM compared with those with non-obstructive HCM (P<0.05). Conclusion MMP-1 is correlated to NT-proBNP, LVOTPG and LVEF, which is valued to the diagnosis of left ventricular outflow tract obstruction in HCM patients.
