CAJ | 학술논문

目的：了解空腹血糖受损（IFG）患者糖耐量异常（IGT）情况及其影响因素。方法纳入空腹血糖为5.6～6.1 mmol/L的IFG患者337例，检测患者口服75克葡萄糖后2小时血糖等资料，分析患者IGT情况及其影响因素。结果纳入的337例IFG患者中46.6%（157/337）伴有IGT。口服葡萄糖耐量异常和正常组超重和肥胖率分别为75.0%和63.1%（P＜0.05）；口服葡萄糖耐量异常组甘油三酯水平显著高于正常组，高密度脂蛋白胆固醇水平低于正常组，均有统计学差异（P＜0.05）。多因素Logistic回归分析结果显示，年龄、体重指数、甘油三酯水平是IFG患者葡萄糖耐量异常的影响因素，相对危险分别为：1.06（95%CI：1.03～1.08）；1.11（95%CI：1.05～119）；1.58（95%CI：1.23～2.09）。进一步对体重正常者发生糖耐量异常的影响因素进行分析，除年龄外，甘油三酯水平是空腹血糖受损患者糖耐量异常的影响因素，相对危险为2.10（95%CI：1.29～3.43）。结论空腹血糖受损患者约半数伴有糖耐量异常，体重指数和甘油三酯水平是空腹血糖受损患者糖耐量异常的影响因素。
목적：료해공복혈당수손（IFG）환자당내량이상（IGT）정황급기영향인소。방법납입공복혈당위5.6～6.1 mmol/L적IFG환자337례，검측환자구복75극포도당후2소시혈당등자료，분석환자IGT정황급기영향인소。결과납입적337례IFG환자중46.6%（157/337）반유IGT。구복포도당내량이상화정상조초중화비반솔분별위75.0%화63.1%（P＜0.05）；구복포도당내량이상조감유삼지수평현저고우정상조，고밀도지단백담고순수평저우정상조，균유통계학차이（P＜0.05）。다인소Logistic회귀분석결과현시，년령、체중지수、감유삼지수평시IFG환자포도당내량이상적영향인소，상대위험분별위：1.06（95%CI：1.03～1.08）；1.11（95%CI：1.05～119）；1.58（95%CI：1.23～2.09）。진일보대체중정상자발생당내량이상적영향인소진행분석，제년령외，감유삼지수평시공복혈당수손환자당내량이상적영향인소，상대위험위2.10（95%CI：1.29～3.43）。결론공복혈당수손환자약반수반유당내량이상，체중지수화감유삼지수평시공복혈당수손환자당내량이상적영향인소。
Objective To get to know the status of impaired oral glucose tolerance (IGT) and influencing factors in patients with impaired fasting glucose (IFG). Methods IFG patients (n=337, FPG being 5.6 mmol/L-6.1 mmol/L) were chosen and their data of age, sex, diabetes family history, height, weight, waistline, blood pressure and blood fat were collected. The level of blood glucose was detected after patients taken 75 g glucose for 2 h, and the status of IGT and influencing factors were analyzed. Results Among 337 IFG patients 46.6%of them (157/337) had IGT. The proportion of overweight and obesity was 75.0%in abnormal group and 63.1%in normal group (P<0.05). The level of triglyceride (TG) was higher and level of high-density lipoprotein-cholesterol (HDL-C) was lower in abnormal group compared with normal group (P<0.05). The multi-factor Logistic regression analysis showed that age, body mass index (BMI) and TG level were influencing factors of IGT, and relative risk was, respectively, 1.06 (95%CI:1.03-1.08), 1.11 (95%CI:1.05-119) and 1.58 (95%CI:1.23-2.09). The further analysis on influencing factors in IFG patients with normal weight showed that, besides of age, TG level was a influencing factor of IGT and relative risk was 2.10 (95%CI:1.29-3.43). Conclusion There are about half of IFG patients with IGT, and BMI and TG level are influencing factors of IGT.