CAJ | 학술논문

Maspin基因作为一种肿瘤抑制基因，在乳腺、口腔等肿瘤中表现出抑制细胞运动、增殖和肿瘤新生血管生成等重要作用，进而抑制肿瘤的发生和发展。目前治疗口腔鳞癌主要靠手术以及放化疗，缺少有效的靶向治疗，因而寻找有效的生物标志物对开发口腔鳞癌的靶向治疗具有重要意义，本文从该基因的来源、结构、作用、以及其在口腔鳞状细胞癌中的相关研究予以综述。
Maspin기인작위일충종류억제기인，재유선、구강등종류중표현출억제세포운동、증식화종류신생혈관생성등중요작용，진이억제종류적발생화발전。목전치료구강린암주요고수술이급방화료，결소유효적파향치료，인이심조유효적생물표지물대개발구강린암적파향치료구유중요의의，본문종해기인적래원、결구、작용、이급기재구강린상세포암중적상관연구여이종술。
Maspin, a member of the serpin family of protease inhibitors, is known to have tumor suppressor functions. Maspin seems to act on the cell membrane to inhibit cell motility, multiplication and tumor angiogenesis in breast carcinoma , oral cavity cancer etc. So far, as we’ re short of targeted therapy, looking forward an effective molecular marker is very significant, or we will only treat oral squamous cell carcinoma ( OS-CC) by surgery, radiotherapy and chemotherapy. The present study synthesized the source, structure, function and biological role of Maspin in OS-CC.