CAJ | 학술논문

目的：分析胃癌术后患者实施FOLFOX方案化疗不同阶段证候演变规律。方法收集150例经胃镜和病理检查确诊为胃癌，并手术治疗后的患者，在对以上患者实施FOLFOX方案化疗的过程中，观察不同化疗阶段中医证型分布的情况。结果①150例胃癌患者性别统计结果显示，男性89例，女性61例；年龄统计结果，60~69岁患者比例最高，占38.67%，其次是50~59岁，占29.33%，30~49岁最少，仅占6%.②中医证候的出现频率由高到低依次为瘀阻胃络证（28.67%）、脾胃虚寒证（24.67%）、脾虚痰湿证（19.33%）、气血两虚证（12.66%）、肝胃不和证（8.67%）、胃热阴虚证（6.00%）。③胃癌术后患者中医证型与术前相比，P<0.05；化疗1次后与术后相比，P>0.05；化疗3次后与化疗1次后相比，P<0.05；化疗6次后与化疗3次后相比，P>0.05。结论①胃癌的发病率男性高于女性，发病年龄以50~69岁居多；②胃癌患者术前中医证候的出现频率由高到低依次为瘀阻胃络证、脾胃虚寒证、脾虚痰湿证、气血两虚证、肝胃不和证、胃热阴虚证。③胃癌患者的中医证型瘀阻胃络证、脾虚痰湿证，在手术后明显减少，而胃热阴虚证、气血两虚证明显增多；实施FOLFOX方案化疗后，胃热阴虚、气血两虚证所占的比值呈增高趋势。
목적：분석위암술후환자실시FOLFOX방안화료불동계단증후연변규률。방법수집150례경위경화병리검사학진위위암，병수술치료후적환자，재대이상환자실시FOLFOX방안화료적과정중，관찰불동화료계단중의증형분포적정황。결과①150례위암환자성별통계결과현시，남성89례，녀성61례；년령통계결과，60~69세환자비례최고，점38.67%，기차시50~59세，점29.33%，30~49세최소，부점6%.②중의증후적출현빈솔유고도저의차위어조위락증（28.67%）、비위허한증（24.67%）、비허담습증（19.33%）、기혈량허증（12.66%）、간위불화증（8.67%）、위열음허증（6.00%）。③위암술후환자중의증형여술전상비，P<0.05；화료1차후여술후상비，P>0.05；화료3차후여화료1차후상비，P<0.05；화료6차후여화료3차후상비，P>0.05。결론①위암적발병솔남성고우녀성，발병년령이50~69세거다；②위암환자술전중의증후적출현빈솔유고도저의차위어조위락증、비위허한증、비허담습증、기혈량허증、간위불화증、위열음허증。③위암환자적중의증형어조위락증、비허담습증，재수술후명현감소，이위열음허증、기혈량허증명현증다；실시FOLFOX방안화료후，위열음허、기혈량허증소점적비치정증고추세。
Objective Analysis of postoperative gastric cancer patients with chemotherapy of FOLFOX regimen in different stages of development of syndrome. Methods Collection of 150 cases diagnosed by gastroscopy and pathology of gastric cancer,and after treatment of the patients with operation,in the process of the implementation of FOLFOX chemotherapy on patients in the above,to observe the distribution of TCM syndromes in different stages of chemotherapy. Results ①Results 150 cases of patients with gastric cancer statistics show gender,male 89 cases,61 cases of women;the statistical results of age,the highest proportion of aged 60-69 patients,accounted for 38.67%,the second is 50-59 years old,accounted for 29.33%,at least 30-49 years old,only 6%.②TCM syndrome of frequency from high to low is gastric blood stasis syndrome (28.67%)、syndrome of deficient cold of spleen and stomach (24.67%)、syndrome of phlegm-dampness due to spleen deficiency (19.33%)、syndrome of deficiency of both qi and blood(12.66%)、syndrome of incoordination between liver and stomach(8.67%)、Stomach yin deficiency(6.00%). ③Compared with the postoperative gastric cancer patients with TCM and preoperative,P<0.05;after first times of chemotherapy and postoperative compared,P>0.05;after third times of chemotherapy and chemotherapy first times compared to,P<0.05;after sixth times of chemotherapy and chemotherapy third times compared to,P>0.05. Conclusion ①The incidence of gastric cancer in men than women,age 50-69 years of age;②Patients with gastric cancer before the emergence of TCM Syndromes of frequency from high to low is syndrome of static blood in stomach collaterals、syndrome of deficient cold of spleen and stomach、syndrome of phlegm-dampness due to spleen deficiency、syndrome of deficiency of both qi and blood、syndrome of incoordination between liver and stomach、Stomach yin deficiency. ③Gastric cancer patients with TCM syndrome types of syndrome of static blood in stomach collaterals、syndrome of phlegm-dampness due to spleen deficiency,decreased significantly after the operation,Stomach yin deficiency、syndrome of deficiency of both qi and blood increased significantly;the implementation of FOLFOX chemotherapy, stomach yin deficiency、syndrome of deficiency of both qi and blood ratios accounted for an increased trend.