CAJ | 학술논문

目的：评价氨基酸配方营养粉辅助治疗婴儿特应性皮炎（atopic dermatitis,ad）的效果。方法特应性皮炎选取我院儿童保健科门诊根据 Williams 标准诊断为特应性皮炎（atopic dermatitis,ad）、年龄小于6月龄的人工喂养婴儿。通过连续给予氨基酸配方营养粉替代喂养7～14天，同时回避鸡蛋、奶制品等易引起过敏的食物。观察婴儿特应性皮炎的改善情况，采用 scorad 评分对特应性皮炎 ad 的严重程度进行评估。结果入组受试者150例，平均年龄（109±72）（15～181）天，其中轻中度 ad 122例，平均 scorad 评分为28.2±6.3（16.5～38.5），重度 ad 28例，平均 scorad 评分为48.7±9.2（40.5～69.7），纳入疗效可评估受试者共142例。采用氨基酸配方营养粉替代喂养7天和14天的总有效率分别为36.8%和72.5%，具有显著的统计学差异（ P <0.0001)。轻中度 ad 组和重度 ad 组，氨基酸配方营养粉替代喂养2周的总有效率均优于1周的总有效率（P <0.001 Vs P <0.05)。合并用药的受试者总有效率显著优于无合并用药的受试者（ P =0.034）。研究过程中未出现严重不良反应。结论通过氨基酸配方营养粉辅助治疗婴儿特应性皮炎（atopic dermatitis,ad）7～14天，对于改善6月龄内婴儿轻中度和重度 ad 具有一定效果，联合应用保湿剂和外用药物治疗等疗效更为显著。
목적：평개안기산배방영양분보조치료영인특응성피염（atopic dermatitis,ad）적효과。방법특응성피염선취아원인동보건과문진근거 Williams 표준진단위특응성피염（atopic dermatitis,ad）、년령소우6월령적인공위양영인。통과련속급여안기산배방영양분체대위양7～14천，동시회피계단、내제품등역인기과민적식물。관찰영인특응성피염적개선정황，채용 scorad 평분대특응성피염 ad 적엄중정도진행평고。결과입조수시자150례，평균년령（109±72）（15～181）천，기중경중도 ad 122례，평균 scorad 평분위28.2±6.3（16.5～38.5），중도 ad 28례，평균 scorad 평분위48.7±9.2（40.5～69.7），납입료효가평고수시자공142례。채용안기산배방영양분체대위양7천화14천적총유효솔분별위36.8%화72.5%，구유현저적통계학차이（ P <0.0001)。경중도 ad 조화중도 ad 조，안기산배방영양분체대위양2주적총유효솔균우우1주적총유효솔（P <0.001 Vs P <0.05)。합병용약적수시자총유효솔현저우우무합병용약적수시자（ P =0.034）。연구과정중미출현엄중불량반응。결론통과안기산배방영양분보조치료영인특응성피염（atopic dermatitis,ad）7～14천，대우개선6월령내영인경중도화중도 ad 구유일정효과，연합응용보습제화외용약물치료등료효경위현저。
Objective to evaluate the formula of amino acid nutrition powder in adjuvant treatment of infantile atopic dermatitis (atopic dermatitis, ad) effect. Method of atopic dermatitis in children health care department of our hospital were selected according to the Williams criteria for diagnosis of atopic dermatitis (atopic dermatitis, ad), younger than June age artificial infant feeding. through the continuous administration of amino acid nutrition powder feeding 7 to 14 days, while avoiding egg, dairy products, easy to cause food allergies. observation of infantile atopic dermatitis to improve the situation, atopic dermatitis severity of ad were evaluated by scorad score. Results of 150 cases in the group of subjects, mean age (109 ± 72) days (15 ~ 181), including 122 cases of mild and moderate AD, the mean SCORAD score was 28.2 ± 6.3 (16.5 ~38.5), 28 cases with severe AD, the mean SCORAD score was 48.7 ± 9.2 (40.5 ~ 69.7), the effect can be incorporated into the the subjects were assessed in 142 cases. the formula of amino acid nutrition powder feeding for 7 days and 14 days of total effective rate were 36.8% and 72.5%, with significant statistical difference (P< 0.0001). Mild to moderate severe AD group and AD group, the total effective rate of amino acid nutrition powder feeding 2 weeks than 1 weeks total efficiency (P&lt VS; 0.001 P< 0.05). The subjects of the combined medication total efficiency is better than no drug combination of subjects (P =0.034). no serious adverse drug reaction occurred in the course of the study. Conclusion the formula of amino acid nutrition powder in adjuvant treatment of infantile atopic dermatitis (atopic dermatitis, ad) 7 to 14 days, for improving the baby in June age of mild to moderate and severe ad has a certain effect, therapeutic effect of combined use of moisturizers and topical drug treatment is more significant.