CAJ | 학술논문

目的：回顾性分析经体外受精-胚胎移植技术治疗后的新生儿情况，总结相关数据，进一步探讨引起体外受精-胚胎移植新生儿结局的因素。方法选择2008年1月到2010年12月因行体外受精/卵泡浆内单精子注射-胚胎移植（IVF/ICSI-ET）技术而于山东烟台毓璜顶医院产科分娩患者536例共694例婴儿作为试验组，随机选取同科室同时间自然妊娠的424例共443例婴儿作为对照组。结果与对照组相比，试验组剖宫产率、早产率、低体重儿比率、多胎妊娠率均升高，差异有统计学意义（P＜0.05），但试验组的单胎与对照组的单胎相比较，除剖宫产率仍升高，早产率及低体重儿比率无明显统计学差别（P＞0.05），当试验组分为年龄≥35岁与年龄＜35岁时，早产率及低体重儿比率无明显差别（P＞0.05）。结论体外受精-胚胎移植后新生儿结局差的主要原因是由于高的多胎妊娠率造成的，年龄的增高与此结局无明显关系。
목적：회고성분석경체외수정-배태이식기술치료후적신생인정황，총결상관수거，진일보탐토인기체외수정-배태이식신생인결국적인소。방법선택2008년1월도2010년12월인행체외수정/란포장내단정자주사-배태이식（IVF/ICSI-ET）기술이우산동연태육황정의원산과분면환자536례공694례영인작위시험조，수궤선취동과실동시간자연임신적424례공443례영인작위대조조。결과여대조조상비，시험조부궁산솔、조산솔、저체중인비솔、다태임신솔균승고，차이유통계학의의（P＜0.05），단시험조적단태여대조조적단태상비교，제부궁산솔잉승고，조산솔급저체중인비솔무명현통계학차별（P＞0.05），당시험조분위년령≥35세여년령＜35세시，조산솔급저체중인비솔무명현차별（P＞0.05）。결론체외수정-배태이식후신생인결국차적주요원인시유우고적다태임신솔조성적，년령적증고여차결국무명현관계。
Objective To evaluate the neonatal outcomes of pregnancies resulting from in vitro fertilization and to investigated the possible higher risks of adverse health outcomes in infants conceived using IVF. Methods Our study includes 443 infants born to 424 women after natural conception as control group and 694 infants born to 536 women that had IVF/ICSI as experimental group. The study was conducted at the Department of Obstetrics at the Yu Huang Ding Hospital from 2008 to 2010. Results Our results showed significant differences between the neonatal and obstetric outcomes of IVF/ICSI and natural conception pregnancies. When referred to singletons only, there were no significant differences in the neonatal and obstetric outcomes between the IVF and the control group. The IVF group was divided into two sub-groups according to the patient’s age: age<35, age≥35. There was no significant difference between the two groups in all observed outcomes. Conclusion The neonatal outcomes of IVF/ICSI were closely associated with the increased incidence of multiple pregnancies following IVF, but it was not conclusively proved when referred to the increasing age of subfertile women.