CAJ | 학술논문

目的：观察补肾活血方治疗帕金森病的临床效果。方法选择西安交通大学第二附属医院2006年9月~2012年9月门诊及住院帕金森病患者70例，将其随机分为治疗组(35例)和对照组(35例)，治疗组给予补肾活血中药和西药美多巴，对照组单用美多巴，疗程均为3个月，采用英国帕金森病学会脑库帕金森病临床诊断量表(UPDRS)对两组患者治疗前后的症状进行评分；同时观察两组患者的非运动症状，包括失眠、便秘、多汗、精神障碍、乏力、不明原因导致的疼痛、认知障碍等的发生率。结果治疗组用药前后的UPDRS评分差较对照组大，差异有统计学意义(P<0.05)；治疗后治疗组的非运动症状，如失眠、便秘、多汗、乏力的发生率与对照组比较，差异有统计学意义(P<0.05)；而精神障碍、不明原因导致的疼痛、认知障碍等虽较对照组有所降低，但差异无统计学意义(P>0.05)。结论补肾活血方可明显改善帕金森病患者的运动症状，同时对于非运动症状如失眠、便秘、多汗、乏力等亦有明显的改善。
목적：관찰보신활혈방치료파금삼병적림상효과。방법선택서안교통대학제이부속의원2006년9월~2012년9월문진급주원파금삼병환자70례，장기수궤분위치료조(35례)화대조조(35례)，치료조급여보신활혈중약화서약미다파，대조조단용미다파，료정균위3개월，채용영국파금삼병학회뇌고파금삼병림상진단량표(UPDRS)대량조환자치료전후적증상진행평분；동시관찰량조환자적비운동증상，포괄실면、편비、다한、정신장애、핍력、불명원인도치적동통、인지장애등적발생솔。결과치료조용약전후적UPDRS평분차교대조조대，차이유통계학의의(P<0.05)；치료후치료조적비운동증상，여실면、편비、다한、핍력적발생솔여대조조비교，차이유통계학의의(P<0.05)；이정신장애、불명원인도치적동통、인지장애등수교대조조유소강저，단차이무통계학의의(P>0.05)。결론보신활혈방가명현개선파금삼병환자적운동증상，동시대우비운동증상여실면、편비、다한、핍력등역유명현적개선。
Objective To observe the clinical efficacy of Bushen Huoxue Decoction on Parkinson disease. Methods 70 cases of Parkinson disease were randomly divided into treatment group (35 cases) and control group (35 cases). All the cases came from the out-patients and in-patients of the Second Affiliated Hospital of Xi'an Jiaotong University from September 2006 to September 2012. In treatment group, Bushen Huoxue Decoction and madopar were administered. In control group, madopar was only administered. The duration of treatment was 3 months. The unified Parkinson disease rating scale (UPDRS) was used to score the symptoms and physical signs before and after medication in two groups. The incidence of non-motor symptoms of two groups was observed, including insomnia, profuse sweating, mental distur-bance, fatigue, unknown pain, cognitive dysfunction, etc.. Results Before and after treatment, UPDRS scores were much more different in treatment group when compared with control group, indicating a statistically significant difference (P<0.05). After medication, in treatment group, of non- motor symptoms, the incidences of insomnia, defecation dysfunc-tion, profuse sweating and fatigue were significantly different in statistics when compared with control group (P<0.05);and those of mental disturbance, unknown pain and cognitive dysfunction decreased as compared with control group, but there was no significant difference (P> 0.05). Conclusion Bushen Huoxue Decoction can improve apparently not only in the motor symptoms of the patients with Parkinson disease but also in many non-motor symptoms patient such as insomnia, defecation dysfunction, profuse sweating and fatigue.