CAJ | 학술논문

目的：探讨对美沙拉秦肠溶片、布拉氏酵母菌散和康复新液治疗溃疡性结肠炎的临床效果,为合理选择药物提供参考。方法选择2012年1月~2013年12月河北北方学院附属第三医院消化科门诊和住院部确诊为轻、中度溃疡性结肠炎患者70例,随机分为治疗组和对照组,每组各35例。治疗组选用口服美沙拉秦肠溶片,布拉氏酵母菌散,将50 mL康复新原液加温至37~40℃,保留灌肠,每晚1次；对照组选用口服美沙拉秦肠溶片的方法进行治疗,比较两组患者的临床疗效。结果治疗6周后观察,治疗组患者腹痛、腹泻、黏液脓血便及大便次数等症状均比单服美沙拉秦肠溶片对照组患者明显改善,差异有统计学意义(P<0.05)。治疗组完全缓解24例,有效7例,无效4例,总有效率为89豫；对照组完全缓解14例,有效1例,无效20例,总有效率为43豫,两组治疗效果比较,差异有统计学意义(P<0.05)。结论美沙拉秦肠溶片、布拉氏酵母菌散和康复新液治疗溃疡性结肠炎疗效确切,值得在临床推广应用。
목적：탐토대미사랍진장용편、포랍씨효모균산화강복신액치료궤양성결장염적림상효과,위합리선택약물제공삼고。방법선택2012년1월~2013년12월하북북방학원부속제삼의원소화과문진화주원부학진위경、중도궤양성결장염환자70례,수궤분위치료조화대조조,매조각35례。치료조선용구복미사랍진장용편,포랍씨효모균산,장50 mL강복신원액가온지37~40℃,보류관장,매만1차；대조조선용구복미사랍진장용편적방법진행치료,비교량조환자적림상료효。결과치료6주후관찰,치료조환자복통、복사、점액농혈편급대편차수등증상균비단복미사랍진장용편대조조환자명현개선,차이유통계학의의(P<0.05)。치료조완전완해24례,유효7례,무효4례,총유효솔위89예；대조조완전완해14례,유효1례,무효20례,총유효솔위43예,량조치료효과비교,차이유통계학의의(P<0.05)。결론미사랍진장용편、포랍씨효모균산화강복신액치료궤양성결장염료효학절,치득재림상추엄응용。
Objective To investigate the clinical efficacy of Mesalazine Enteric-coated Tablet, Saccharomyces Boulardii Sachet and Kangfuxin Solution in treating ulcerative colitis, and provide a reference for a reasonable choice of drugs. Methods 70 outpatients and inpatients with mild-moderate ulcerative colitis in Department of Gastroenterology, the Third Affiliated Hospital of Hebei Northern Institute, from January 2012 to December 2013, were randomly divided into the treatment group (35 cases) and the control group (35 cass). The treatment group were given Mesalazine Enteric-coated Tablet, Saccharomyces Boulardii Sachet and Kangfuxin Solution (50 mL) in 37-40℃for retention-enema once a day, while the control group was given Mesalazine Enteric-coated Tablet only. The clinical effect was compared. Re-sults The clinical symptoms of abdominal pain, diarrhea, mucous stool with pus and blood, stool frequency and so on in treatment group 6 weeks after the treatment were all better than those in control group, the differences were statistically significant (P<0.05). In treatment group, 24 cases were remarkably effective, 7 cases were effective, 4 cases were in-effective and the effective rate was 89%; while in the control group, 14 cases were remarkably effective, 1 cases were effective and 20 cases were ineffective, the effective rate was 43%, there was statistically significant difference in ther-apeutic effect between two groups (P< 0.05). Conlusion Mesalazine Enteric-coated Tablet, Saccharomyces Boulardii Sachet and Kangfuxin Solution can effectively improve relative symptom in treating ulcerative colitis. It has reliable clinical effect and it is worthy of clinical application.