中国医药导报
中國醫藥導報
중국의약도보
CHINA MEDICAL HERALD
2014年
22期
33-36
,共4页
老年脑梗死%高尿酸血症%神经功能
老年腦梗死%高尿痠血癥%神經功能
노년뇌경사%고뇨산혈증%신경공능
Elderly cerebral infarction%Hyperuricemia%Neurological function
目的：讨论高尿酸血症(HUA)与老年脑梗死及其神经功能缺损程度的关系。方法选择2012年10月~2014年2月北京市回民医院(以下简称“我院”)110例老年急性脑梗死患者作为研究组,并选择同期我院56例健康体检者作为对照组。检测并比较两组血尿酸(UA)、低密度脂蛋白胆固醇(LDL-C)、血糖(Glu)、收缩压(SBP)、舒张压(DBP)水平,研究血UA水平与患者病情严重程度的关系。结果①研究组患者血浆UA、LDL-C、Glu水平[(343.65±70.15)μmol/L、(3.28±0.49)mmol/L、(6.45±1.55)mmol/L]均显著高于对照组[(259.55±74.58)μmol/L、(2.58±0.42)mmol/L、(5.92±1.34)mmol/L],差异有统计学意义(P<0.05或P<0.01)。②多因素Logistic回归分析结果显示,血UA水平升高(OR=1.020,95%CI：1.011~1.030)、高血压(OR=1.206,95%CI：1.091~1.333)、糖尿病(OR=1.678,95%CI：1.052~2.676)和高LDL-C血症(OR=2.473,95%CI：1.252~3.676)是老年脑梗死的独立危险因素。③研究组中随着病情程度分层递增,血UA水平逐步增高,差异有高度统计学意义(P<0.01)。结论 HUA是老年脑梗死的独立、可干预的危险因素,并可提示老年脑梗死病情的严重程度。
目的：討論高尿痠血癥(HUA)與老年腦梗死及其神經功能缺損程度的關繫。方法選擇2012年10月~2014年2月北京市迴民醫院(以下簡稱“我院”)110例老年急性腦梗死患者作為研究組,併選擇同期我院56例健康體檢者作為對照組。檢測併比較兩組血尿痠(UA)、低密度脂蛋白膽固醇(LDL-C)、血糖(Glu)、收縮壓(SBP)、舒張壓(DBP)水平,研究血UA水平與患者病情嚴重程度的關繫。結果①研究組患者血漿UA、LDL-C、Glu水平[(343.65±70.15)μmol/L、(3.28±0.49)mmol/L、(6.45±1.55)mmol/L]均顯著高于對照組[(259.55±74.58)μmol/L、(2.58±0.42)mmol/L、(5.92±1.34)mmol/L],差異有統計學意義(P<0.05或P<0.01)。②多因素Logistic迴歸分析結果顯示,血UA水平升高(OR=1.020,95%CI：1.011~1.030)、高血壓(OR=1.206,95%CI：1.091~1.333)、糖尿病(OR=1.678,95%CI：1.052~2.676)和高LDL-C血癥(OR=2.473,95%CI：1.252~3.676)是老年腦梗死的獨立危險因素。③研究組中隨著病情程度分層遞增,血UA水平逐步增高,差異有高度統計學意義(P<0.01)。結論 HUA是老年腦梗死的獨立、可榦預的危險因素,併可提示老年腦梗死病情的嚴重程度。
목적：토론고뇨산혈증(HUA)여노년뇌경사급기신경공능결손정도적관계。방법선택2012년10월~2014년2월북경시회민의원(이하간칭“아원”)110례노년급성뇌경사환자작위연구조,병선택동기아원56례건강체검자작위대조조。검측병비교량조혈뇨산(UA)、저밀도지단백담고순(LDL-C)、혈당(Glu)、수축압(SBP)、서장압(DBP)수평,연구혈UA수평여환자병정엄중정도적관계。결과①연구조환자혈장UA、LDL-C、Glu수평[(343.65±70.15)μmol/L、(3.28±0.49)mmol/L、(6.45±1.55)mmol/L]균현저고우대조조[(259.55±74.58)μmol/L、(2.58±0.42)mmol/L、(5.92±1.34)mmol/L],차이유통계학의의(P<0.05혹P<0.01)。②다인소Logistic회귀분석결과현시,혈UA수평승고(OR=1.020,95%CI：1.011~1.030)、고혈압(OR=1.206,95%CI：1.091~1.333)、당뇨병(OR=1.678,95%CI：1.052~2.676)화고LDL-C혈증(OR=2.473,95%CI：1.252~3.676)시노년뇌경사적독립위험인소。③연구조중수착병정정도분층체증,혈UA수평축보증고,차이유고도통계학의의(P<0.01)。결론 HUA시노년뇌경사적독립、가간예적위험인소,병가제시노년뇌경사병정적엄중정도。
Objective To investigate the relationship between hyperuricemia (HUA) and cerebral infarction in the elderly and the degree of neurological deficit. Methods 110 elderly patients with cerebral infarction from October 2012 to February 2014 in the Muslim Hospital of Beijing (“our hospital” for short) were selected as study group, and 56 healthy persons in the same period in our hospital were enrolled as control group. The levels of blood uric acid (UA), low density lipoprotein cholesterol (LDL-C), blood glucose (Glu), SBP, DBP in the two groups were measured and compared, and the relationship between the levels of serum UA and the severity of the disease was studied. Results① The serum levels of UA, LDL-C, Glu in study group [(343.65±70.15)μmol/L, (3.28±0.49) mmol/L, (6.45±1.55) mmol/L] were higher than those of the control group [(259.55±74.58) μmol/L, (2.58±0.42) mmol/L, (5.92±1.34) mmol/L], the differences were statistically significant (P<0.05 or P<0.01).②Multivariate Logistic regression analysis showed that high levels of the UA (OR=1.020, 95%CI:1.011-1.030), hypertension (OR=1.206, 95%CI:1.091-1.333), diabetes (OR=1.678, 95%CI:1.0052-2.676), and high levels of low-density protein (OR=2.473, 95%CI:1.252-3.676) were independent risk factors of cerebral infarction in elderly.③With the severity increasing, the blood uric acid level elevated gradually in patients, the differences were statistically significant (P< 0.01). Conclusion HUA is an independent and preventive intervention risk factor for cerebral infarction in the elderly and may predict the severity of cerebral infarction in the elderly.
