CAJ | 학술논문

目的：运用Meta分析方法评价中国人群中血清胸腺激酶1(TK1)与乳腺疾病的相关性。方法通过计算机检索中国知网( CNKI)、万方、维普、PubMed 数据库,结合文献追溯和采用公共搜索引擎( www. baidu. com； scholar. google. com)网上检索,收集所有关于中国人群中血清TK1与乳腺疾病的相关性的研究。以血清TK1与乳腺疾病的相关性的相对危险度(RR)值及标化均数差(SMD)值为效应指标,各资料间进行一致性检验,以确定采用固定或随机效应模型进行合并分析。发表偏倚通过漏斗图和Egger′s线性回归检验进行评估。统计分析应用RevMan5.1软件进行,Egger’ s线性回归检验选用STATA 10.0软件计算。结果共入选相关文献15篇, Meta分析显示血清TK1在乳腺癌患者与乳腺良性疾病患者及健康人群之间比较差异均有统计学意义(P<0．05)；血清TK1在淋巴结转移及无转移组间以及不同分期间差异无统计学意义。结论血清TK1水平对乳腺癌及乳腺良性疾病的鉴别有一定的参考价值；而对预测及评估乳腺癌患者中是否存在淋巴结转移以及评估乳腺癌分期的参考价值较低。
목적：운용Meta분석방법평개중국인군중혈청흉선격매1(TK1)여유선질병적상관성。방법통과계산궤검색중국지망( CNKI)、만방、유보、PubMed 수거고,결합문헌추소화채용공공수색인경( www. baidu. com； scholar. google. com)망상검색,수집소유관우중국인군중혈청TK1여유선질병적상관성적연구。이혈청TK1여유선질병적상관성적상대위험도(RR)치급표화균수차(SMD)치위효응지표,각자료간진행일치성검험,이학정채용고정혹수궤효응모형진행합병분석。발표편의통과루두도화Egger′s선성회귀검험진행평고。통계분석응용RevMan5.1연건진행,Egger’ s선성회귀검험선용STATA 10.0연건계산。결과공입선상관문헌15편, Meta분석현시혈청TK1재유선암환자여유선량성질병환자급건강인군지간비교차이균유통계학의의(P<0．05)；혈청TK1재림파결전이급무전이조간이급불동분기간차이무통계학의의。결론혈청TK1수평대유선암급유선량성질병적감별유일정적삼고개치；이대예측급평고유선암환자중시부존재림파결전이이급평고유선암분기적삼고개치교저。
Objective To evaluate the correlation of TK1 and breast disease among Chinese by Meta-analysis. Methods Related studies were collected by retrieving literatures in PubMed, CNKI,Vip and Wanfang Databases. In addition, searching related literatures on the internet ( www. baidu. com and scholar. google. com) and tracing back literatures were also carried out. The correlation was evaluated by Risk Ratio ( RR ) and Standard Mean Difference ( SMD) . Fixed or random effect models were selected to analyze the data, based on the heterogeneity tested by chi-square test. Publication bias was assessed by funnel plot and Egger′s test afterwards. Egger′s tests were conducted with STATA 10. 0 software . Other statistical analyses were conducted with Review Manager 5. 1 . Results 15 studies were selected. Meta-analysis showed that the statistical differences of serum TK1 level between and breast cancer, benign breast disease and healthy people were significant, while it was insignificant between the group of lymph node metastasis and non-metastasis group, as well as the different stages. Conclusion Serum TK1 is useful for evaluating breast cancer and benign breast disease, whereas it might not be useful to predict the lymph node metastasis and different stage of breast cancer. However, we assume that not all studies were collected and the collected ones are of low methodological quality. Thus, high quality research with large samples and multi-centers are needed to further the knowledge of the application of TK1 to the breast disease.