CAJ | 학술논문

目的探讨儿童脑弥漫性轴索损伤(DAI)的临床表现、诊断、治疗及预后.方法回顾性分析北京儿童医院神经外科自2009年1月至2012年6月收治并确诊的32例弥漫性轴索损伤患儿的临床资料,并对患儿进行跟踪随访.结果经过(26.7±17.3)个月的随访,32例患儿无一例死亡,恢复良好28例(87.5％),轻残2例(6.25％),重残2例(6.25％),无植物生存.结论生命体征平稳后尽早行头颅MRI检查可以更为及时准确地诊断DAI;应用包括重症监护、亚低温、降颅压、神经营养、激素、钙离子阻滞剂、高压氧等非手术综合治疗措施可以有效的治疗儿童弥漫性轴索损伤,其预后好于成人.
목적 탐토인동뇌미만성축색손상(DAI)적림상표현、진단、치료급예후.방법 회고성분석북경인동의원신경외과자2009년1월지2012년6월수치병학진적32례미만성축색손상환인적림상자료,병대환인진행근종수방.결과 경과(26.7±17.3)개월적수방,32례환인무일례사망,회복량호28례(87.5％),경잔2례(6.25％),중잔2례(6.25％),무식물생존.결론 생명체정평은후진조행두로MRI검사가이경위급시준학지진단DAI;응용포괄중증감호、아저온、강로압、신경영양、격소、개리자조체제、고압양등비수술종합치료조시가이유효적치료인동미만성축색손상,기예후호우성인.
Objective To explore the manifestation,diagnosis,management strategy and outcome of the diffuse axonal injury (DAD in children.Methods Thirty-two patients with DAI were admitted to Beijing Children Hospital from the January 2009 to December 2012.Their clinical data were retrospectively analyzed.Results Through a mean follow up time of 26.7 ± 17.3 months,there was no death.Twenty-eight patients were in good recovery; 2 had mild disability; 2 had severe disability.Conclusions Early MRI examination (soon after stabilization) can make the diagnosis of DAI more timely and accurate.Comprehensive therapy including intensive care,mild hypothermia,reducing intracranial pressure,neurotrophin,hormones,calcium block,hyperbaric oxygen may help improve outcome.