CAJ | 학술논문

目的：报告多孔磷酸三钙(tricalciumphosphate，TCP)治疗38例腔隙性骨缺损患者至少随访2年的临床效果。方法2008年3月至2011年9月，对38例腔隙性骨缺损患者采用多孔磷酸三钙填充修复，男22例，女16例。年龄3～58岁，平均23岁。缺损范围最小0.72cm3，最大151.88cm3，平均35.62cm3。随访25～65个月，平均41个月。采用在体TCP人工骨降解的X线片并图像分析软件分析植骨区灰度变化，计算材料降解率，动态观察多孔磷酸三钙人工骨降解情况。结果所有患者术后未见任何过敏或毒性反应。随时间延长，人工骨材料逐渐降解，新骨逐渐形成，以术后1年内降解速度最快。患者年龄越小(＜16岁)、肿瘤体积越小(＜10cm3)，新骨成骨、材料降解速度越快。结论多孔磷酸三钙人工骨可以用作良性或侵袭性骨肿瘤骨缺损的修复，平均随访41个月，疗效满意。
목적：보고다공린산삼개(tricalciumphosphate，TCP)치료38례강극성골결손환자지소수방2년적림상효과。방법2008년3월지2011년9월，대38례강극성골결손환자채용다공린산삼개전충수복，남22례，녀16례。년령3～58세，평균23세。결손범위최소0.72cm3，최대151.88cm3，평균35.62cm3。수방25～65개월，평균41개월。채용재체TCP인공골강해적X선편병도상분석연건분석식골구회도변화，계산재료강해솔，동태관찰다공린산삼개인공골강해정황。결과소유환자술후미견임하과민혹독성반응。수시간연장，인공골재료축점강해，신골축점형성，이술후1년내강해속도최쾌。환자년령월소(＜16세)、종류체적월소(＜10cm3)，신골성골、재료강해속도월쾌。결론다공린산삼개인공골가이용작량성혹침습성골종류골결손적수복，평균수방41개월，료효만의。
Objective To assess the over-2-year clinical outcomes of porous tricalcium phosphate ( TCP ) for the repair of lacunar bone defects. Methods A total of 38 patients with lacunar bone defects underwent the repair with porous TCP from March 2008 to September 2011, including 22 males and 16 females, whose average age was 23 years old ( range;3-58 years ). Tumor sizes varied from 0.72 cm3 to 151.88 cm3, with the average size of 35.62 cm3. All patients were followed up for a mean period of 41 months ( range;25-65 months ). The in vivo biodegradation rate of the implanted TCP was evaluated based on the radiographic analyzing method. The gray scale change of the grafting area in plain X-ray images was used to assess the degradation of porous TCP. Results There was neither signiifcant reverse reaction to the transplanted material nor locally inlfammatory reaction in all of the cases. Bone defects were repaired gradually, in company with the degradation of TCP materials and the formation of new bone. The rates of TCP degradation and new bone formation were fastest in the ifrst year postoperatively. The younger the patients were (<16 years old ) and the smaller the tumor size was (<10 cm3 ), the faster the rates were. Conclusions The porous TCP is an ideal material for the repair of lacunar bone defects caused by benign or invasive tumors, and the over-2-year follow-up results are satisfactory .