CAJ | 학술논문

目的了解RF在pSS中的临床意义.方法回顾性分析141例皖南医学院附属弋矶山医院2006-2012年pSS住院患者的临床及实验室资料,分析RF的临床意义.2组间计量数据比较用t检验,率的比较采用x2检验.结果 RF在pSS中的阳性率为49％(63/128),其中低滴度阳性32％(20/63),高滴度阳性占68％ (43/63); RF高滴度阳性的患者较阴性的患者更易出现腮腺肿、关节炎及血液系统累及,实验室检查方面更易出现抗SSA抗体阳性,IgG升高,血小板减少,ESR加快,球蛋白升高;RF低滴度阳性与阴性者间临床表现及实验室检查方面差异无统计学意义;RF高滴度阳性与低滴度阳性间临床表现及实验室检查方面差异无统计学意义.结论 RF高滴度阳性的pSS患者易出现腺体外脏器受累,且炎症指标及抗体水平均较高.
목적 료해RF재pSS중적림상의의.방법 회고성분석141례환남의학원부속익기산의원2006-2012년pSS주원환자적림상급실험실자료,분석RF적림상의의.2조간계량수거비교용t검험,솔적비교채용x2검험.결과 RF재pSS중적양성솔위49％(63/128),기중저적도양성32％(20/63),고적도양성점68％ (43/63); RF고적도양성적환자교음성적환자경역출현시선종、관절염급혈액계통루급,실험실검사방면경역출현항SSA항체양성,IgG승고,혈소판감소,ESR가쾌,구단백승고;RF저적도양성여음성자간림상표현급실험실검사방면차이무통계학의의;RF고적도양성여저적도양성간림상표현급실험실검사방면차이무통계학의의.결론 RF고적도양성적pSS환자역출현선체외장기수루,차염증지표급항체수평균교고.
Objective To explore the clinical significance of rheumatoid factor (RF) in primary SjSgren's syndrome (pSS).Methods The clinical and laboratory data of 141 cases of hospitalized pSS patients from Wannan Medical College Affiliated Yijishan Hospital from 2006 to 2012 were analyzed retrospectively,and the clinical significance of RF was also analyzed.The data were analyzed using t-test and ~ test respectively.Results The positive rate of RF in pSS was 49％ (63/128),the rate of low-titer positive RF was 32％ (20/63),and the high-titer positive RF was 68％ (43/63).Patients with high-titer positive RF were more prone to suffer from parotidomegaly,arthritis and hematological system involvement.In terms of the results of laboratory examination,the following were more frequent,including positive anti-SSA antibody,the elevated IgG level,the decrease of platelet,the increase of erythrocyte sedimentation rate (ESR) and the increase of total globulin level.For the respect of clinical performance and laboratory examination between patients with low-titer positive RF and negative RF,no difference was found statistically.Conclusion pSS patients with high-titer positive RF are prone to have extraglandular organ involvement,and acute-phase reactants and antibody levels are relatively high.