内蒙古医科大学学报
內矇古醫科大學學報
내몽고의과대학학보
Journal of Inner Mongolia Medical University
2014年
2期
114-118
,共5页
慢性阻塞性肺病%噻托溴铵%沙美特罗/氟替卡松%疗效
慢性阻塞性肺病%噻託溴銨%沙美特囉/氟替卡鬆%療效
만성조새성폐병%새탁추안%사미특라/불체잡송%료효
chronic obstructive pulmonary disease%tiotropium%salmeterol/fluticasone%efficacy
目的：研究联合吸入噻托溴铵和沙美特罗/氟替卡松治疗慢性阻塞性肺病的临床效果。方法：将中重度慢性阻塞性肺病病人随机分成观察组和对照组,每组30例。所有病人均给予常规抗感染、吸氧、化痰和平喘对症治疗。对照组给予沙美特罗/氟替卡松50/500μg,2次/d,观察组在此基础上加用噻托溴铵18μg,1次/d。观察2组治疗前及治疗8 wk后的临床症状、肺功能及动脉血气变化。结果：治疗前2组肺功能及动脉血气差异均无统计学意义(P>0.05)；观察组治疗8wk后第一秒用力呼气容积(FEV1)、FEV1/FVC(用力肺活量)(%)、FEV1占预计值百分比( FEV1%)显著提高,临床症状和动脉血气指标明显改善,与对照组比较,差异有统计学意义(P<0.05)。结论：联合使用噻托溴铵和沙美特罗/氟替卡松较单独使用沙美特罗/氟替卡松对中重度COPD病人临床症状、肺功能及动脉血气有更加明显的改善作用。
目的：研究聯閤吸入噻託溴銨和沙美特囉/氟替卡鬆治療慢性阻塞性肺病的臨床效果。方法：將中重度慢性阻塞性肺病病人隨機分成觀察組和對照組,每組30例。所有病人均給予常規抗感染、吸氧、化痰和平喘對癥治療。對照組給予沙美特囉/氟替卡鬆50/500μg,2次/d,觀察組在此基礎上加用噻託溴銨18μg,1次/d。觀察2組治療前及治療8 wk後的臨床癥狀、肺功能及動脈血氣變化。結果：治療前2組肺功能及動脈血氣差異均無統計學意義(P>0.05)；觀察組治療8wk後第一秒用力呼氣容積(FEV1)、FEV1/FVC(用力肺活量)(%)、FEV1佔預計值百分比( FEV1%)顯著提高,臨床癥狀和動脈血氣指標明顯改善,與對照組比較,差異有統計學意義(P<0.05)。結論：聯閤使用噻託溴銨和沙美特囉/氟替卡鬆較單獨使用沙美特囉/氟替卡鬆對中重度COPD病人臨床癥狀、肺功能及動脈血氣有更加明顯的改善作用。
목적：연구연합흡입새탁추안화사미특라/불체잡송치료만성조새성폐병적림상효과。방법：장중중도만성조새성폐병병인수궤분성관찰조화대조조,매조30례。소유병인균급여상규항감염、흡양、화담화평천대증치료。대조조급여사미특라/불체잡송50/500μg,2차/d,관찰조재차기출상가용새탁추안18μg,1차/d。관찰2조치료전급치료8 wk후적림상증상、폐공능급동맥혈기변화。결과：치료전2조폐공능급동맥혈기차이균무통계학의의(P>0.05)；관찰조치료8wk후제일초용력호기용적(FEV1)、FEV1/FVC(용력폐활량)(%)、FEV1점예계치백분비( FEV1%)현저제고,림상증상화동맥혈기지표명현개선,여대조조비교,차이유통계학의의(P<0.05)。결론：연합사용새탁추안화사미특라/불체잡송교단독사용사미특라/불체잡송대중중도COPD병인림상증상、폐공능급동맥혈기유경가명현적개선작용。
Objective:To study the clinical efficacy on combined inhaled tiotropium bromide and salmeterol/fluticasone in the treatment of chronic obstructive pulmonary disease ( COPD ) . Methods:patients with moderate and severe COPD were randomly divided into two groups ( n=30 for each group) ,experimental group and control group. All patients were treated with routine anti-infection, oxygen inhalation, relieving phlegm and anti-asthma. The control group was given Salmeterol/fluticasone(50/500μg) twice daily, added tiotropium bromide 18 ug once daily to the observation group. Observe the chang of clinical symptoms、pulmonary function examination and blood gas analysis before treatment and after treatment eight weeks In two group. Result:There were no significant differences in the values of pulmonary function and arterial blood gas before treatment between two groups(P>0. 05). forced expiratory volume in 1 second(FEV1)、FEV1/FVC(forced vital capacity)、FEV1%、clinical symptoms and arterial blood gas index significantly improve after treatment eight weeks in patients of experimental group, Compared with the control group, there were significant differences in the values(P<0. 05). Conclusion:Combination therapy with tiotropium and Salmeterol/fluticason leads to better improved clinical symptoms、lung function and arterial blood gas as compared to salmeterol/fluticasion alone in the treatment of patients with moderate and severe COPD.
