CAJ | 학술논문

目的：研究制备蛇床子素微乳，并对其理化性质进行考察。方法以油酸乙酯、肉豆蔻酸异丙酯（IPM）、角鲨烷为油相，以Tween-80、PEG-40氢化蓖麻油（PEG-40）、乙氧基化加氢羊毛脂为表面活性剂，以无水乙醇、1，2-丙二醇、丙三醇为助表面活性剂，通过伪三元相图的绘制对微乳组分进行筛选确定；并以微乳外观、粒径及其分布、黏度、电导率、电位、折光率等为指标，初步考察蛇床子素微乳的理化性质。结果蛇床子素微乳的处方组合为：IPM∶水∶PEG-40∶1，2-丙二醇：蛇床子素的质量比为1∶1．8∶2．3∶6．9∶0．1。蛇床子素微乳为澄清透明，有蓝色乳光的液体，10000 r· min-1离心10 min 后无分层、浑浊现象，其平均粒径为（55．1±1．3）nm，黏度为（10．3±0．32）mm2· s-1，电导率为（124±0．16）μs·cm-1，电位为（-0．54±0．002）mv，折光率为（1．5373±0．0002）。结论蛇床子素微乳理化性质稳定，有望成为蛇床子素的一种新型给药制剂。
목적：연구제비사상자소미유，병대기이화성질진행고찰。방법이유산을지、육두구산이병지（IPM）、각사완위유상，이Tween-80、PEG-40경화비마유（PEG-40）、을양기화가경양모지위표면활성제，이무수을순、1，2-병이순、병삼순위조표면활성제，통과위삼원상도적회제대미유조분진행사선학정；병이미유외관、립경급기분포、점도、전도솔、전위、절광솔등위지표，초보고찰사상자소미유적이화성질。결과사상자소미유적처방조합위：IPM∶수∶PEG-40∶1，2-병이순：사상자소적질량비위1∶1．8∶2．3∶6．9∶0．1。사상자소미유위징청투명，유람색유광적액체，10000 r· min-1리심10 min 후무분층、혼탁현상，기평균립경위（55．1±1．3）nm，점도위（10．3±0．32）mm2· s-1，전도솔위（124±0．16）μs·cm-1，전위위（-0．54±0．002）mv，절광솔위（1．5373±0．0002）。결론사상자소미유이화성질은정，유망성위사상자소적일충신형급약제제。
Objective To study the preparation of osthole microemulsion and investigate its physio-chemical properties.Methods Ethyl oleate,IPM and squalane were taken as oil phase.Tween-80,PEG-40 and ethoxylated lanolin were taken as surfactants.Absolute ethyl alcohol,1 ,2-propylene glycol and glyc-erol were as cosurfactants.Pseudo-ternary phase diagram was used to screen and determine microemulsion components.The appearance,particle size and viscosity of microemulsion,electrical conductivity,potential and refractive index were taken as the indicators to investigate preliminarily the physiochemical properties of osthole microemulsion.Results The recipe of osthole microemulsion:IPM∶water∶PEG-40∶1 ,2-propylene glycol:mass of osthole microemulsion were 1∶1 .8∶2.3∶6.9∶0.1 .Osthole microemulsion was clear and trans-parent and was blue opalescence liquid.The layering and turbidity were not presented after centrifugation at 10 000 r·min-1 for10min.The mean particle size:55.1 ±1.3 nm,the viscosity:10.3 ±0.32 mm-2·s-1, electrical conductivity:1 24 ±0.1 6 μs·cm-1 ,potential:-0.54 ±0.002 mv and refractive index:1 .537 3 ± 0.000 2.Conclusion Osthole microemulsion is stable in physiochemical properties and expected to be the new preparation of osthole.