CAJ | 학술논문

目的：探讨早期糖尿病肾病（DN）患者中医证候与影响因素的相关性，为DN的防治提供理论依据。方法：选取符合西医诊断标准的早期DN样本，共236例，运用单因素和多元Logistic回归统计分析。结果：气阴两虚证的危险因素主要有体质量指数（BMI）、年龄、病程、冠心病、高血压、脉无力；阴虚燥热证的危险因素主要有吸烟，甘油三酯（TG）、尿微量白蛋白（UMA）升高，舌红、苔黄；脾肾气虚证的危险因素有苔白；瘀证的危险因素有TG、UMA升高，舌紫暗；痰瘀证的危险因素有苔黄燥、脉弦滑；湿热证的危险因素有运动情况、胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）升高、苔黄厚。结论：早期DN中医证候之间存在一定的差异，临床辨证诊断及治疗应考虑上述因素的影响。
목적：탐토조기당뇨병신병（DN）환자중의증후여영향인소적상관성，위DN적방치제공이론의거。방법：선취부합서의진단표준적조기DN양본，공236례，운용단인소화다원Logistic회귀통계분석。결과：기음량허증적위험인소주요유체질량지수（BMI）、년령、병정、관심병、고혈압、맥무력；음허조열증적위험인소주요유흡연，감유삼지（TG）、뇨미량백단백（UMA）승고，설홍、태황；비신기허증적위험인소유태백；어증적위험인소유TG、UMA승고，설자암；담어증적위험인소유태황조、맥현활；습열증적위험인소유운동정황、담고순（TC）、저밀도지단백담고순（LDL-C）승고、태황후。결론：조기DN중의증후지간존재일정적차이，림상변증진단급치료응고필상술인소적영향。
This study was aimed to explore the relationship between traditional Chinese medicine (TCM) syndrome distribution characteristics and influential factors of early-stage diabetic nephropathy (DN) patients in order to pro-vide theoretical basis for DN prevention and treatment. A total of 236 early-stage DN cases were selected in con-sistency with western diagnostic criteria. The single-factor and multivariate logistic regression were used in the sta-tistical analysis. The results showed that the risk factors of qi-yin deficiency syndrome contained body mass index (BMI), age, disease course, coronary heart disease (CHD), hypertension, and weak pulse. Risk factors of yin-defi-ciency and dryness-heat syndrome contained smoking, TG and UMA elevation, red tongue with yellow coating. Risk factor of qi-deficiency of spleen and kidney syndrome contained white coating. Risk factors of stasis syndrome con-tained TG and UMA elevation, and dark purplish tongue. Risk factors of phlegm-stasis syndrome contained yellow and dryness coating, wiry and slippery pulse. Risk factors of damp-heat syndrome contained sports, TC, LDL-C el-evation, yellow and thick coating. It was concluded that there were some differences among TCM syndromes in the early-stage of DN. Therefore, the clinical syndrome diagnosis and treatment should consider influential factors men-tioned above.