世界科学技术-中医药现代化
世界科學技術-中醫藥現代化
세계과학기술-중의약현대화
WORLD SCIENCE AND TECHNOLOGY-MODERNIZATION OF TRADITIONAL CHINESE MEDICINE
2014年
3期
634-637
,共4页
归脾丸%培土生血%持续性血液透析%慢性肾脏病贫血%微炎症状态
歸脾汍%培土生血%持續性血液透析%慢性腎髒病貧血%微炎癥狀態
귀비환%배토생혈%지속성혈액투석%만성신장병빈혈%미염증상태
Gui-Pi pills%enriching the blood by tonifying spleen%maintenance hemodialysis%anemia in chronic kidney disease%micro-inflammatory state
目的：从调节微炎症状态角度揭示归脾丸改善运用持续性血液透析（MHD）技术的慢性肾脏病（CKD）5期患者CKD贫血的效应机制，进而探索“培土生血”的科学内涵。方法：60例西医诊断为CKD 5期、CKD贫血，中医诊断为脾虚、血虚证的MHD患者随机分成两组，每组30例。对照组采用促红细胞生成素（EPO）干预治疗，治疗组采用归脾丸联合EPO治疗，疗程为60天，两组治疗前后分别检测血细胞比容（Hct）、血红蛋白（Hb）、红细胞数（RBC）、EPO、高敏C反应蛋白（hs-CRP）、肿瘤坏死因子-α（TNF-α）、白介素-6（IL-6）。结果：与治疗前比较，治疗后两组患者贫血相关指标Hct、Hb、RBC、EPO皆有明显升高（P<0.05或P<0.01），两组患者干预后上述贫血指标及临床疗效比较，治疗组明显高于对照组（P<0.05）。与治疗前比较，治疗后两组患者炎症相关指标hs-CRP、IL-6、TNF-α皆有明显下降（P<0.05或P<0.01），两组患者上述炎症指标干预后比较，治疗组明显低于对照组（P<0.05或P<0.01）。结论：归脾丸具有抗炎补血作用，此为其培土生血机制之一。
目的：從調節微炎癥狀態角度揭示歸脾汍改善運用持續性血液透析（MHD）技術的慢性腎髒病（CKD）5期患者CKD貧血的效應機製，進而探索“培土生血”的科學內涵。方法：60例西醫診斷為CKD 5期、CKD貧血，中醫診斷為脾虛、血虛證的MHD患者隨機分成兩組，每組30例。對照組採用促紅細胞生成素（EPO）榦預治療，治療組採用歸脾汍聯閤EPO治療，療程為60天，兩組治療前後分彆檢測血細胞比容（Hct）、血紅蛋白（Hb）、紅細胞數（RBC）、EPO、高敏C反應蛋白（hs-CRP）、腫瘤壞死因子-α（TNF-α）、白介素-6（IL-6）。結果：與治療前比較，治療後兩組患者貧血相關指標Hct、Hb、RBC、EPO皆有明顯升高（P<0.05或P<0.01），兩組患者榦預後上述貧血指標及臨床療效比較，治療組明顯高于對照組（P<0.05）。與治療前比較，治療後兩組患者炎癥相關指標hs-CRP、IL-6、TNF-α皆有明顯下降（P<0.05或P<0.01），兩組患者上述炎癥指標榦預後比較，治療組明顯低于對照組（P<0.05或P<0.01）。結論：歸脾汍具有抗炎補血作用，此為其培土生血機製之一。
목적：종조절미염증상태각도게시귀비환개선운용지속성혈액투석（MHD）기술적만성신장병（CKD）5기환자CKD빈혈적효응궤제，진이탐색“배토생혈”적과학내함。방법：60례서의진단위CKD 5기、CKD빈혈，중의진단위비허、혈허증적MHD환자수궤분성량조，매조30례。대조조채용촉홍세포생성소（EPO）간예치료，치료조채용귀비환연합EPO치료，료정위60천，량조치료전후분별검측혈세포비용（Hct）、혈홍단백（Hb）、홍세포수（RBC）、EPO、고민C반응단백（hs-CRP）、종류배사인자-α（TNF-α）、백개소-6（IL-6）。결과：여치료전비교，치료후량조환자빈혈상관지표Hct、Hb、RBC、EPO개유명현승고（P<0.05혹P<0.01），량조환자간예후상술빈혈지표급림상료효비교，치료조명현고우대조조（P<0.05）。여치료전비교，치료후량조환자염증상관지표hs-CRP、IL-6、TNF-α개유명현하강（P<0.05혹P<0.01），량조환자상술염증지표간예후비교，치료조명현저우대조조（P<0.05혹P<0.01）。결론：귀비환구유항염보혈작용，차위기배토생혈궤제지일。
This article was aimed to reveal the effect mechanism of improving anemia among stage 5 of chronic kidney disease (CKD) patients with maintenance hemodialysis (MHD) interfering by Gui-Pi (GP) pills from adjusting of micro-inflammatory state, in order to explore the scientific connotation of "enriching blood by tonifying spleen". A total of 60 MHD patients with the diagnosis of stage 5 of CKD, renal anemia in western medicine, and spleen deficiency, blood deficiency syndrome in traditional Chinese medicine (TCM) diagnosis, were randomly divided into two groups, with 30 patients in each group. Erythropoietin (EPO) therapy was used in the control group; and GP pills combined with EPO treatment was used in the treatment group. The treatment course was 60 days. Indicators, including Hct, Hb, RBC, EPO, hs-CRP, TNF-α and IL-6 were detected before and after treatment in both groups. The results showed that compared with pretreatment, the anemia related indicators such as Hct, Hb, RBC, EPO were obviously increased after interfering with EPO (P < 0.05 or P < 0.01). Comparison on anemia indicators and clinical therapeutic effect after interfering between two groups showed that the treatment group was better than the control group with statistical significance(P< 0.05). Compared with pretreatment, the inflammation related indicators such as hs-CRP, IL-6, TNF-α were obviously decreased (P < 0.05 or P < 0.01). Comparison on inflammation related indicators after interfering showed that the treatment group was lower than the control group with statistical significance (P < 0.05 or P < 0.01). It was concluded that GP pills has the effect of anti-inflammation and enrich blood. It is one of the mechanisms of "enriching blood by tonifying spleen".
