CAJ | 학술논문

目的：研究COX-2和Ki67在鲍恩病皮损中的表达情况，并探讨两者之间的关系。方法应用免疫组化SP染色法对27例鲍恩病患者皮损及15份正常皮肤组织进行COX-2和Ki67染色。结果 COX-2与Ki67在正常皮肤组织中表达非常低，而在鲍恩病皮损中染色强度显著增高（P＜0.05）。COX-2与Ki67在鲍恩病皮损中的表达水平呈显著正相关（r=0.451，P＜0.05）。结论 COX-2与鲍恩病的发生密切相关，过度表达的COX-2蛋白可能参与肿瘤细胞的增生过程。
목적：연구COX-2화Ki67재포은병피손중적표체정황，병탐토량자지간적관계。방법응용면역조화SP염색법대27례포은병환자피손급15빈정상피부조직진행COX-2화Ki67염색。결과 COX-2여Ki67재정상피부조직중표체비상저，이재포은병피손중염색강도현저증고（P＜0.05）。COX-2여Ki67재포은병피손중적표체수평정현저정상관（r=0.451，P＜0.05）。결론 COX-2여포은병적발생밀절상관，과도표체적COX-2단백가능삼여종류세포적증생과정。
Objective To study the expressions and relationship of COX-2 and Ki67 in Bowen’s disease. Methods Specimens from 27 Bowen's disease patients and 15 normal persons were assayed for COX-2 and Ki67 by immunohistochemistry. Results The expressions of COX-2 and Ki67 in normal skin was very low, but in Bowen's disease was signiifcantly increased. COX-2 was positive correlated with Ki67 in Bowen's disease(r=0.451, P<0.05). Conclusion The abnormal level of COX-2 and Ki67 plays a role in carcinogenesis and development of Bowen's disease, the over-expression of COX-2 may result in the proliferation of tumor cell.