世界科学技术-中医药现代化
世界科學技術-中醫藥現代化
세계과학기술-중의약현대화
WORLD SCIENCE AND TECHNOLOGY-MODERNIZATION OF TRADITIONAL CHINESE MEDICINE
2014年
2期
398-401
,共4页
中医药%病毒性肺炎%症状关联%疗效评价
中醫藥%病毒性肺炎%癥狀關聯%療效評價
중의약%병독성폐염%증상관련%료효평개
Alzheimer's disease%enriching marrow by tonifying kidney%Gui-Lu Er-Xian glue%transcranial doppler%cerebral blood circulation
目的：从调节脑部血液循环角度探讨龟鹿二仙胶干预阿尔茨海默病（AD）的效应机制，进而探索补肾生髓的科学内涵。方法：60例西医诊断为阿尔茨海默病，中医诊断为肾虚髓空证的患者随机分成两组，每组30例。对照组采用安理申干预治疗，治疗组采用龟鹿二仙胶治疗，疗程为60天，两组治疗前后分别监测经颅多普勒超声（TCD）相关参数。结果：与治疗前比较，两组治疗后患者大脑中动脉（MCA）、前动脉（ACA）、后动脉（PCA）、椎动脉（VA）及基底动脉（BA）5脑部血管的收缩期峰值血流速度（Vp）、舒张末期血流速度（Vd）皆明显升高（P<0.05或P<0.01），搏动指数（PI）及阻力指数（RI）皆明显下降（P<0.05或P<0.01）；与对照组比较，治疗后治疗组患者MCA、ACA、PCA、VA及BA 5脑部血管的Vp、Vd皆明显升高（P<0.05或P<0.01），PI、RI皆明显降低（P<0.05或P<0.01）。结论：龟鹿二仙胶具有改善AD患者脑部血液循环的作用，此可能为其补肾生髓的机制之一。
目的：從調節腦部血液循環角度探討龜鹿二仙膠榦預阿爾茨海默病（AD）的效應機製，進而探索補腎生髓的科學內涵。方法：60例西醫診斷為阿爾茨海默病，中醫診斷為腎虛髓空證的患者隨機分成兩組，每組30例。對照組採用安理申榦預治療，治療組採用龜鹿二仙膠治療，療程為60天，兩組治療前後分彆鑑測經顱多普勒超聲（TCD）相關參數。結果：與治療前比較，兩組治療後患者大腦中動脈（MCA）、前動脈（ACA）、後動脈（PCA）、椎動脈（VA）及基底動脈（BA）5腦部血管的收縮期峰值血流速度（Vp）、舒張末期血流速度（Vd）皆明顯升高（P<0.05或P<0.01），搏動指數（PI）及阻力指數（RI）皆明顯下降（P<0.05或P<0.01）；與對照組比較，治療後治療組患者MCA、ACA、PCA、VA及BA 5腦部血管的Vp、Vd皆明顯升高（P<0.05或P<0.01），PI、RI皆明顯降低（P<0.05或P<0.01）。結論：龜鹿二仙膠具有改善AD患者腦部血液循環的作用，此可能為其補腎生髓的機製之一。
목적：종조절뇌부혈액순배각도탐토구록이선효간예아이자해묵병（AD）적효응궤제，진이탐색보신생수적과학내함。방법：60례서의진단위아이자해묵병，중의진단위신허수공증적환자수궤분성량조，매조30례。대조조채용안리신간예치료，치료조채용구록이선효치료，료정위60천，량조치료전후분별감측경로다보륵초성（TCD）상관삼수。결과：여치료전비교，량조치료후환자대뇌중동맥（MCA）、전동맥（ACA）、후동맥（PCA）、추동맥（VA）급기저동맥（BA）5뇌부혈관적수축기봉치혈류속도（Vp）、서장말기혈류속도（Vd）개명현승고（P<0.05혹P<0.01），박동지수（PI）급조력지수（RI）개명현하강（P<0.05혹P<0.01）；여대조조비교，치료후치료조환자MCA、ACA、PCA、VA급BA 5뇌부혈관적Vp、Vd개명현승고（P<0.05혹P<0.01），PI、RI개명현강저（P<0.05혹P<0.01）。결론：구록이선효구유개선AD환자뇌부혈액순배적작용，차가능위기보신생수적궤제지일。
This study was aimed to discuss the effect mechanism of Gui-Lu Er-Xian (GLEX) glue intervention in Alzheimer's disease (AD) from the regulation of cerebral blood circulation and then explore the scientific connotation of tonifying kidney and marrow. A total of 60 patients, who were diagnosed as AD in modern medicine and kidney-marrow deficiency syndrome in traditional Chinese medicine (TCM), were randomly divided into two groups, with 30 patients in each group. Cases in the control group were treated with Donepezil Hydrochloride Tablets. And cases in the treatment group were treated with GLEX. The treatment course was 60 days. Transcranial doppler (TCD) parameters were monitored before and after treatment in both groups. The results showed that compared with pretreatment, Vp, Vd in MCA, ACA, PCA, VA and BA were obviously increased in both groups after treatment (P<0.05 or P< 0.01), and PI, RI were obviously decreased (P< 0.05 or P< 0.01). Compared with the control group, Vp, Vd in MCA, ACA, PCA, VA and BA in the treatment group were obviously higher than the control group after treatment (P< 0.05 or P< 0.01), and PI, RI were obviously decreased (P< 0.05 or P< 0.01). It was concluded that GLEX glue can improve cerebral blood circulation among AD patients. This may be one of the mechanisms of enriching marrow by tonifying kidney.
