国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2014年
12期
1763-1765
,共3页
林荣华%綦巧雯%黄楚君%林明祥
林榮華%綦巧雯%黃楚君%林明祥
림영화%기교문%황초군%림명상
甲泼尼龙琥珀酸钠%儿童%肾变病综合征%疗效%成本
甲潑尼龍琥珀痠鈉%兒童%腎變病綜閤徵%療效%成本
갑발니룡호박산납%인동%신변병종합정%료효%성본
Methylprednisolone%Children%Nephrotic syndrome%Effect%Cost
目的 观察常规剂量甲泼尼龙琥珀酸钠(甲强龙)治疗儿童初发肾病综合征的疗效、不良反应及治疗成本.方法 治疗组20例初发儿童肾病综合征患者予甲强龙1.4 mg/ (kg· d),加入葡萄糖中静脉滴注,至尿蛋白连续3次转阴,后改强的松2 mg/(kg·d)口服治疗,对照组20例初发儿童肾病综合征患者起始予强的松2 mg/(kg·d),分3次口服,至尿蛋白连续3次转阴,观察两组治疗效果、副作用及治疗成本.结果 治疗组水肿消退时间[(10.25±3.782)d]、尿蛋白转阴时间[(14.45±4.383)d]明显优于对照组[(12.85±3.360)d、(18.56±4.196)d];水钠潴留、肝脏损害和院内感染等不良反应发生率低于对照组x 2=4.329,P＜0.05,且治疗成本无明显增加[治疗组:(3419.99±684.90)元,对照组:(3502.80±376.63)元].结论 常规剂量甲泼尼龙琥珀酸钠治疗原发性肾病综合征起效快、疗效好且不良反应少,治疗成本无增加,是一种安全、有效的治疗方法.
目的 觀察常規劑量甲潑尼龍琥珀痠鈉(甲彊龍)治療兒童初髮腎病綜閤徵的療效、不良反應及治療成本.方法 治療組20例初髮兒童腎病綜閤徵患者予甲彊龍1.4 mg/ (kg· d),加入葡萄糖中靜脈滴註,至尿蛋白連續3次轉陰,後改彊的鬆2 mg/(kg·d)口服治療,對照組20例初髮兒童腎病綜閤徵患者起始予彊的鬆2 mg/(kg·d),分3次口服,至尿蛋白連續3次轉陰,觀察兩組治療效果、副作用及治療成本.結果 治療組水腫消退時間[(10.25±3.782)d]、尿蛋白轉陰時間[(14.45±4.383)d]明顯優于對照組[(12.85±3.360)d、(18.56±4.196)d];水鈉潴留、肝髒損害和院內感染等不良反應髮生率低于對照組x 2=4.329,P＜0.05,且治療成本無明顯增加[治療組:(3419.99±684.90)元,對照組:(3502.80±376.63)元].結論 常規劑量甲潑尼龍琥珀痠鈉治療原髮性腎病綜閤徵起效快、療效好且不良反應少,治療成本無增加,是一種安全、有效的治療方法.
목적 관찰상규제량갑발니룡호박산납(갑강룡)치료인동초발신병종합정적료효、불량반응급치료성본.방법 치료조20례초발인동신병종합정환자여갑강룡1.4 mg/ (kg· d),가입포도당중정맥적주,지뇨단백련속3차전음,후개강적송2 mg/(kg·d)구복치료,대조조20례초발인동신병종합정환자기시여강적송2 mg/(kg·d),분3차구복,지뇨단백련속3차전음,관찰량조치료효과、부작용급치료성본.결과 치료조수종소퇴시간[(10.25±3.782)d]、뇨단백전음시간[(14.45±4.383)d]명현우우대조조[(12.85±3.360)d、(18.56±4.196)d];수납저류、간장손해화원내감염등불량반응발생솔저우대조조x 2=4.329,P＜0.05,차치료성본무명현증가[치료조:(3419.99±684.90)원,대조조:(3502.80±376.63)원].결론 상규제량갑발니룡호박산납치료원발성신병종합정기효쾌、료효호차불량반응소,치료성본무증가,시일충안전、유효적치료방법.
Objective To observe effect,adverse reactions and cost of conventional dose Methylprednisolone in the treatment of incipient nephrotic syndrome in children.Methods In treatment group,20 children with incipient nephrotic syndrome were treated with Methylprednisolone [1.4 mg/(kg · d)] by intravenous drip adding in glucose; after negative proteinuria three times in a row,treated with oral prednisolone [2 mg/ (kg · d)].In control group,20 children with incipient nephrotic syndrome were treated with oral prednisolone [2 mg/(kg · d)].Results The time of dropsy fadeaway and proteinuria turning to negative in treatment group were shorter than those in control group [(10.25 ± 3.782)d vs.(12.85 ± 3.360)d,(14.45 ± 4.383)d vs.(18.56 ± 4.196)d].The incidence of water-sodium retention,liver damage and hospital infection in treatment group was lower than that in control group (x2 =4.329,P=0.037).Besides,cost in treatment group did not increase [(3419.99 ± 684.90) in treatment group,(3502.80 ± 376.63) in control group].Conclusion Conventional dose Methylprednisolone in the treatment of incipient nephrotic syndrome in children has fast and good effect,low adverse reactions,without cost increased,which is a safety and effective treatment method.
