CAJ | 학술논문

目的：探讨雄性激素源性脱发(androgenetic alopecia，AGA)患者毛囊活检的临床意义。方法采用毛囊活检方法获取雄性激素源性脱发患者顶部、枕部以及非脱发者顶部毛囊及周围组织标本，观察苏木精-伊红(hematoxylin-eosinstaining， HE)染色并用免疫组织化学法检测雄性激素受体（androgen receptor，AR）的表达。结果患者顶部毛囊及周围组织中HE染色可见单一核细胞浸润，AR表达率79.17%，明显强于枕部（20.83%）和非脱发者顶部（20%）（P<0.05），患者枕部与非脱发者顶部毛囊及周围组织中AR表达无显著性差异（P>0.05）。结论毛囊活检为AGA早期诊断和鉴别诊断提供了手段，也为雄性激素源性脱发患者早期防治提供了依据。
목적：탐토웅성격소원성탈발(androgenetic alopecia，AGA)환자모낭활검적림상의의。방법채용모낭활검방법획취웅성격소원성탈발환자정부、침부이급비탈발자정부모낭급주위조직표본，관찰소목정-이홍(hematoxylin-eosinstaining， HE)염색병용면역조직화학법검측웅성격소수체（androgen receptor，AR）적표체。결과환자정부모낭급주위조직중HE염색가견단일핵세포침윤，AR표체솔79.17%，명현강우침부（20.83%）화비탈발자정부（20%）（P<0.05），환자침부여비탈발자정부모낭급주위조직중AR표체무현저성차이（P>0.05）。결론모낭활검위AGA조기진단화감별진단제공료수단，야위웅성격소원성탈발환자조기방치제공료의거。
Objective To investigate the clinical significance of the hair follicle biopsy to androgenetic alopecia (AGA) pa-tients. Methods We used the hair follicle biopsy technique to obtain the top and the occipital hair follicles and the surrounding tissue of AGA patients and the top of non-alopecia as specimens,and observed the hematoxylin-eosinstaining (HE) staining,and immunohistochemical method was used to detect the androgen receptor (AR) expression. Results The mononuclear cells infiltra-tion were found in the top of AGA’hair follicles and the surrounding tissue by HE staining,the expression of AR was stronger than the occipital of AGA and the top of non-alopecia (P<0.05). There were no significant differences in AR expression between the occipital of AGA and the top of non-alopecia (P>0.05). Conclusion Hair follicle biopsy provides a means for diagnosis and dif-ferential diagnosis of early AGA. It also provides the basis for early prevention of AGA.