CAJ | 학술논문

为了考察苦参苍术口服液的安全性，按《兽药注册资料汇编》的要求，选用小白鼠进行了急性毒性试验。结果显示，苦参苍术口服液灌胃给药的LD50为20.51 mL/kg，相当于生药量68.91 mL/kg，可判断苦参苍术口服液为小毒。95%可信限（可信区间）范围为16.37～25.90 mL/kg，相当于禽临床用量的27.3～43.2倍，说明苦参苍术口服液临床使用安全。
위료고찰고삼창술구복액적안전성，안《수약주책자료회편》적요구，선용소백서진행료급성독성시험。결과현시，고삼창술구복액관위급약적LD50위20.51 mL/kg，상당우생약량68.91 mL/kg，가판단고삼창술구복액위소독。95%가신한（가신구간）범위위16.37～25.90 mL/kg，상당우금림상용량적27.3～43.2배，설명고삼창술구복액림상사용안전。
In order to evaluate the actue toxicity of Kushencangshu oral liquid,the experiment was conducted in accordance with acute toxicity requirements in compilation of veterinary drug registration data. The acute toxicity of Kushencangshu oral liquid was studied in mice in this experiment,the toxicity of Kushencangshu oral liquid was demonstrated by the minimal lethal dose and the LD50 of mice. The results showed that the LD50 of the Kushencangshu oral liquid was 20.51 mL/kg,equal to 68.91 g/kg of the crude drug every day,it had light poi-sonous; the minimal lethal dose ranged between 16.37 and 25.9 mL/kg,which was equivalent to from 27.3 to 43.2 times of daily dosage of poultry. Kushencangshu oral liquid was relatively safe in clinical application.