CAJ | 학술논문

目的：观察无创性肢体缺血预适应( noninvasive delayed limbischemic preconditioning ，NDLIP )对急性脑梗死的疗效。方法选取40例急性脑梗死患者，随机分为NDLIP组和对照组，每组20例。其中NDLIP组于入院后在常规治疗基础上开始给予NDLIP---弹性绷带绑紧大腿根部，造成下肢短时间缺血。3次/d ，5 min/次，间隔10 min。对照组不给予NDLIP ，仅给予常规治疗。对所有病例均于治疗开始及治疗14 d后进行NIHSS评分、Barthel指数( BI )评分和Fugl-Meyer ( FMA )总分评定。结果治疗前两组NIHSS评分、BI及FMA总分评分相近，差异无统计学意义(P＞0.05)。治疗14 d后再次评定两组BI及FMA总分评分均有所提高及NIHSS评分明显降低，但NDLIP组患者提高幅度更大，经t检验两组差异有高度统计学意义(P＜0.01)。结论 NDLIP治疗急性脑梗死可明显减轻临床神经功能缺损程度，提高脑梗死病人日常生活活动能力和肢体运动功能，比单纯常规治疗疗效好。NDLIP有望为脑梗死的临床治疗提供可行的、简便的、有效的治疗手段。
목적：관찰무창성지체결혈예괄응( noninvasive delayed limbischemic preconditioning ，NDLIP )대급성뇌경사적료효。방법선취40례급성뇌경사환자，수궤분위NDLIP조화대조조，매조20례。기중NDLIP조우입원후재상규치료기출상개시급여NDLIP---탄성붕대방긴대퇴근부，조성하지단시간결혈。3차/d ，5 min/차，간격10 min。대조조불급여NDLIP ，부급여상규치료。대소유병례균우치료개시급치료14 d후진행NIHSS평분、Barthel지수( BI )평분화Fugl-Meyer ( FMA )총분평정。결과치료전량조NIHSS평분、BI급FMA총분평분상근，차이무통계학의의(P＞0.05)。치료14 d후재차평정량조BI급FMA총분평분균유소제고급NIHSS평분명현강저，단NDLIP조환자제고폭도경대，경t검험량조차이유고도통계학의의(P＜0.01)。결론 NDLIP치료급성뇌경사가명현감경림상신경공능결손정도，제고뇌경사병인일상생활활동능력화지체운동공능，비단순상규치료료효호。NDLIP유망위뇌경사적림상치료제공가행적、간편적、유효적치료수단。
Objective To observe the curative effect of noninvasive delayed limb ischemic preconditioning (NDLIP ) on the sufferers with acute cerebral infarction .Methods 40 cases with acute cerebral infarction were selected and randomly divided into NDLIP group and control group with 20 cases in each group.The sufferers in the ND LIP group,together with conventional therapy,were preconditioned by tightening the leg end arteries with NDLIP elastic bandage for 5 minutes per time and 3 times a day at an interval of 10 min .While the sufferers in the the control group had only conventional therapy with NDLIP .All patients were provided routine treatment.All sufferers were assessed with theNationalInstitutesofHealthStrokeScale(NIHSS),theBarthelIndex(BI)scores,andtheFugl-Meyermotorfunctionscale(FMA)atthe beginningoftreatmentandonthe14thdayoftreatment.Results TheNIHSS,BIscoresandtheFMAweresimilarbetweenthetwogroups before treatment without statistically significant differences (P>0 .05 ).There were remarkable differences between the two groups after 14 days of treatment,BIscores and the FM Aincreased,the NIH SS decreased in the two groups,while it increased more in the ND LIP group, and t-test showed the differences between the two groups were of high statistical significance (P<0 .01 ).Conclusion NDLIP can alleviate the neurologic impairment in acute cerebral infarction treatment,enhance the activities of daily living and limb motor function .It is better than conventional treatment.NDLIP is expected to provide a feasible,simple and effective route for treating acute cerebral infarction .