CAJ | 학술논문

目的：探讨黏液纤维肉瘤(myxofibrosarcoma，MFS)的临床病理学特征、免疫组化表达特点、鉴别诊断要点。方法收集3例MFS患者的临床及病理资料进行分析，复习相关文献。结果 MFS好发于老年男人，生长缓慢，多见于四肢、少见于躯干。结节状无痛性生长，肿块由梭形和星形的瘤细胞组成、分布于不规则多少一不等的黏液样物中，可见特征性细长弯曲的薄壁小血管、脂肪母细胞样瘤细胞；免疫组化vimentin、CD99瘤细胞3例均弥漫阳性，1例SMA、1例S-100局灶阳性。结论 MFS是一种伴有黏液样变的纤维母细胞性恶性肿瘤，多发生于老年人四肢皮下或深部肌层，临床表现为局部缓慢增大的无痛性肿块。容易误诊为软组织的良肿瘤或其它恶性肿瘤。
목적：탐토점액섬유육류(myxofibrosarcoma，MFS)적림상병이학특정、면역조화표체특점、감별진단요점。방법수집3례MFS환자적림상급병리자료진행분석，복습상관문헌。결과 MFS호발우노년남인，생장완만，다견우사지、소견우구간。결절상무통성생장，종괴유사형화성형적류세포조성、분포우불규칙다소일불등적점액양물중，가견특정성세장만곡적박벽소혈관、지방모세포양류세포；면역조화vimentin、CD99류세포3례균미만양성，1례SMA、1례S-100국조양성。결론 MFS시일충반유점액양변적섬유모세포성악성종류，다발생우노년인사지피하혹심부기층，림상표현위국부완만증대적무통성종괴。용역오진위연조직적량종류혹기타악성종류。
Objective To investigate the mucus fibrosarcoma (myxofibrosarcoma, MFS) clinicopathological features, immunohistochemical expression features, differential diagnosis. Methods three cases the clinical and pathological data were analyzed MFS patients, review of the literature. Results MFS occurs in older men, slow growth, more common in the limbs, rare in the trunk. Painless nodular growth, tumor composed of spindle and stel ate tumor cells, irregularly distributed in an unequal number of mucus-like material, the visible characteristic elongated curved thin-wal ed smal blood vessels, fat-like mother cells immunohistochemical vimentin, CD99 tumor cells were diffusely positive three cases, one case of SMA, one cases focal S-100 positive tumor cells. Conclusions MFS is a conclusion with myxoid variant fibroblasts malignancy, occurs in the elderly or deep subcutaneous muscular limbs, clinical manifestations of local slowly increasing painless mass. Easily misdiagnosed as benign soft tissue tumors or other malignancies.