CAJ | 학술논문

目的：观察采用静脉注射免疫球蛋白（IN IG ）治疗癫痫患儿的疗效，并对其发病的机制进行分析。方法这74例癫痫患儿随机平均分成2组，每组37例。将选取其中一组采用在卡马西平治疗同时静脉注射免疫球蛋白（IN IG ）进行治疗的癫痫患儿作为观察组，将选取另一组采用卡马西平治疗同时添加托吡酯进行治疗的癫痫患儿作为对照组。观察2组治疗后的临床效果。结果经过治疗后，2组的临床效果有明显的不同，观察组的总有效率（89.19％）明显高于对照组的总有效率（62.17％），差异有统计学上意义（ P＜0.05）。并且治疗后，观察组的癫痫患儿的淋巴细胞亚群等降低的程度明显优于对照组的癫痫患儿，差异有统计学上意义（P＜0.05）。结论癫痫患儿采用静脉注射免疫蛋白（INIG）治疗的疗效更显著，值得广泛运用在临床上。
목적：관찰채용정맥주사면역구단백（IN IG ）치료전간환인적료효，병대기발병적궤제진행분석。방법저74례전간환인수궤평균분성2조，매조37례。장선취기중일조채용재잡마서평치료동시정맥주사면역구단백（IN IG ）진행치료적전간환인작위관찰조，장선취령일조채용잡마서평치료동시첨가탁필지진행치료적전간환인작위대조조。관찰2조치료후적림상효과。결과경과치료후，2조적림상효과유명현적불동，관찰조적총유효솔（89.19％）명현고우대조조적총유효솔（62.17％），차이유통계학상의의（ P＜0.05）。병차치료후，관찰조적전간환인적림파세포아군등강저적정도명현우우대조조적전간환인，차이유통계학상의의（P＜0.05）。결론전간환인채용정맥주사면역단백（INIG）치료적료효경현저，치득엄범운용재림상상。
Objective To observe the efficacy of intravenous immunoglobulin (INIG) in the treatment of epilepsy in chil-dren and analyze the possible mechanisms .Methods Seventy -four children with epilepsy treated in our hospital were selected as the research objects ,and were randomly divided them into two equal groups ,37 cases in each group .The group treated with intravenous immunoglobulin (INIG) as the observation group ,another group was treated with add topiramate as the control group .The clinical efficacy was observed and the possible mechanisms of children with epilepsy after treatment in the two groups were comparatively analyzed .Results After treatment ,the clinical efficacy of two groups were significantly different , the total effective rate of observation group (89 .19% ) was significantly higher than that of control group (62 .17% ) ,it was statistically significant (P<0 .05) .And the reduced degree of lymphocyte subpopulation in children with epilepsy of observa-tion group was significantly better than the control group after treatment ,it was statistically significant (P<0 .05) .Conclusion The efficacy of intravenous immunoglobulin (INIG) in the treatment of children with epilepsy is significant ,it is worthy of wide application in clinic .