CAJ | 학술논문

目的：探讨MMP2表达与子宫内膜腺癌临床参数和预后之间相关性。方法我们收集了81例子宫内膜腺癌患者石蜡标本。这些患者的年龄在32~80岁之间。随后，利用免疫组化SP方法检测了81例子宫内膜腺癌中MMP2表达情况。最后，我们使用SPSS软件统计分析了MMP2表达与与子宫内膜腺癌进展和预后之间相关性。结果MMP2在子宫内膜腺癌胞浆中表达。此外，过表达的MMP2与子宫内膜腺癌分化程度（P=0.015）以及预后（P=0.041）呈负性相关。结论MMP2过表达是子宫内膜腺癌患者的一个恶性标志物。
목적：탐토MMP2표체여자궁내막선암림상삼수화예후지간상관성。방법아문수집료81례자궁내막선암환자석사표본。저사환자적년령재32~80세지간。수후，이용면역조화SP방법검측료81례자궁내막선암중MMP2표체정황。최후，아문사용SPSS연건통계분석료MMP2표체여여자궁내막선암진전화예후지간상관성。결과MMP2재자궁내막선암포장중표체。차외，과표체적MMP2여자궁내막선암분화정도（P=0.015）이급예후（P=0.041）정부성상관。결론MMP2과표체시자궁내막선암환자적일개악성표지물。
Objective To explore the expression of MMP2 and its correlation with the clinical features and prognosis of endometrial adenocarcinoma. Methods We collected paraffin- embedded samples from 81 patients with endometrial adenocarcinoma aged 32 to 80 years to examine the expression of MMP2 using immunohistochemistry. The correlation of MMP2 expression with the clinical characteristics and prognosis of the patients was analyzed. Results MMP2 protein was expressed in the cytoplasm of the tumor cells. MMP2 over-expression was negatively correlated with tumor differentiation (P=0.015) and prognosis (P=0.041) of endometrial adenocarcinoma. Conclusion MMP2 over-expression is a potential malignant biomarker in endometrial adenocarcinoma.