CAJ | 학술논문

目的：初步探讨6种常见过敏食物的主要过敏蛋白与IgA肾病发病的关系。方法采用ELISA双抗体夹心法检测并比较31例IgA肾病患者及80例健康体检者血清中6种常见过敏食物的主要过敏蛋白特异性的IgA1、IgG及IgE水平，并对所有病人进行食物过敏情况问卷调查，观察多种食物抗体水平均明显升高的患者的临床特征。结果 IgA肾病组患者血清中6种常见过敏食物的主要过敏蛋白特异性的IgA1及IgG水平均显著高于健康对照组（P<0.05）。两组中均未检测到食物特异性的IgE。所有病人均无明确的食物过敏史。多种食物（大于4种）特异性IgG抗体水平均明显升高的患者均有蛋白尿。结论某些食物尤其是高致敏性食物在IgA肾病的发病及进程中可能伴有重要角色。
목적：초보탐토6충상견과민식물적주요과민단백여IgA신병발병적관계。방법채용ELISA쌍항체협심법검측병비교31례IgA신병환자급80례건강체검자혈청중6충상견과민식물적주요과민단백특이성적IgA1、IgG급IgE수평，병대소유병인진행식물과민정황문권조사，관찰다충식물항체수평균명현승고적환자적림상특정。결과 IgA신병조환자혈청중6충상견과민식물적주요과민단백특이성적IgA1급IgG수평균현저고우건강대조조（P<0.05）。량조중균미검측도식물특이성적IgE。소유병인균무명학적식물과민사。다충식물（대우4충）특이성IgG항체수평균명현승고적환자균유단백뇨。결론모사식물우기시고치민성식물재IgA신병적발병급진정중가능반유중요각색。
Objective To explore the relationship between the major allergens of 6 common allergic foods and IgA nephropathy. Methods A sensitive sandwich enzyme-linked immunosorbent assay (ELISA) was used to detect the serum levels of food-specific IgA1, IgG and IgE in 31 patients with IgA nephropathy and 80 healthy volunteers. All the patients were examined for a history of food allergy using a questionnaire. Results Serum levels of IgA1 and IgG against the major allergens of the 6 common allergic foods were significantly higher in patients with IgA nephropathy than in healthy volunteers (P<0.05). There was no detectable food-specific IgE antibodies in the two groups. No patients had a clear history of food allergy. All the patients with increased IgG levels specific to 4 or more foods simultaneously had proteinuria. Conclusion Some foods especially the highly allergic ones may participate in the pathogenesis and progression of IgA nephropathy.