CAJ | 학술논문

糖尿病是严重危害人类健康的常见病,然而其发病机制并不完全清楚.线粒体的主要功能是合成ATP为机体提供能量,此外还在活性氧产生、细胞钙稳态和细胞凋亡中起重要的调节作用.导致线粒体功能障碍的重要原因包括氧化应激、钙紊乱、线粒体生物合成减少、线粒体内膜通透性转变孔道开放以及线粒体DNA突变等.越来越多的研究表明,线粒体功能障碍不仅与1型糖尿病的β-细胞功能障碍有关,也与2型糖尿病的胰岛素抵抗密切相关,还在糖尿病心肌病的发生发展中起重要作用.笔者就线粒体功能障碍与糖尿病及其心肌病的研究现状作一综述,有助于认识并深入研究线粒体功能障碍在糖尿病中的重要作用,为阐明糖尿病的发病机制及其临床防治拓开新思路.
당뇨병시엄중위해인류건강적상견병,연이기발병궤제병불완전청초.선립체적주요공능시합성ATP위궤체제공능량,차외환재활성양산생、세포개은태화세포조망중기중요적조절작용.도치선립체공능장애적중요원인포괄양화응격、개문란、선립체생물합성감소、선립체내막통투성전변공도개방이급선립체DNA돌변등.월래월다적연구표명,선립체공능장애불부여1형당뇨병적β-세포공능장애유관,야여2형당뇨병적이도소저항밀절상관,환재당뇨병심기병적발생발전중기중요작용.필자취선립체공능장애여당뇨병급기심기병적연구현상작일종술,유조우인식병심입연구선립체공능장애재당뇨병중적중요작용,위천명당뇨병적발병궤제급기림상방치탁개신사로.
Diabetes mellitus is a common disease of serious harmful to human health,but its pathogenesis is not entirely clear.Mitochondria are the important organelles to generate energy in eukaryocytes,and play a pivotal role in the regulation of reactive oxygen species generation,intracellular calcium homeostasis,and apoptosis signal transduction.The possible causes of mitochondrial dysfunction include oxidative stress,Ca2+ disturbances,reduction of mitochondrial biosynthesis,opening of mitochondrial permeability transition pore,mitochondrial DNA mutations,and etc..Many studies demonstrate that mitochondrial dysfunction is associated with β-cell dysfunction of type 1 diabetes mellitus and insulin resistance of type 2 diabetes mellitus.Moreover,mitochondrial dysfunction plays important roles in the development of diabetic cardiomyopathy.This present article reviewed the current status of studies on the relationship of mitochondrial dysfunction and diabetes mellitus and diabetic cardiomyopathy.It is very important to understand and study mitochondrial dysfunction and its important roles in diabetes mellitus and diabetic cardiomyopathy in order to clarify the pathogenesis of diabetes mellitus and explore new approaches of prevention and treatment for diabetes mellitus.