中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2014年
5期
540-542
,共3页
前列腺癌%膀胱出口梗阻%绿激光汽化术%睾丸切除术
前列腺癌%膀胱齣口梗阻%綠激光汽化術%睪汍切除術
전렬선암%방광출구경조%록격광기화술%고환절제술
Advanced prostate cancer%Bladder outlet obstruction%The green light photoselective vaporization%Testicular resection
目的 评估应用绿激光汽化术(PVP)联合睾丸切除加抗雄激素治疗晚期前列腺癌并膀胱出口梗阻的效果.方法 回顾性分析20例采用PVP联合睾丸切除加抗雄激素治疗晚期前列腺癌并膀胱出口梗阻患者的临床资料.结果 全部患者均手术治疗成功.最大尿流率从术前(2.0±1.0) ml/s升至(14.0±4.5) ml/s,血清前列腺特异性抗原从术前(176.5±160.5)μg/L降至(2.0±1.0)μg/L,国际前列腺症状评分从术前(25.0±5.0)分降至(8.0±1.0)分,生活质量评分从术前(4.0±2.0)分降至(1.0±1.0)分.手术前、后比较差异均有统计学意义(t值分别为9.502、7.371、5.238、8.350,P均＜0.05).随访3 ～18个月,临床症状明显改善,排尿满意,全部带瘤存活.结论 PVP联合睾丸切除术加抗雄激素治疗晚期前列腺癌常合并膀胱出口梗阻,能有效改善后尿道梗阻症状,提高了患者生活质量.
目的 評估應用綠激光汽化術(PVP)聯閤睪汍切除加抗雄激素治療晚期前列腺癌併膀胱齣口梗阻的效果.方法 迴顧性分析20例採用PVP聯閤睪汍切除加抗雄激素治療晚期前列腺癌併膀胱齣口梗阻患者的臨床資料.結果 全部患者均手術治療成功.最大尿流率從術前(2.0±1.0) ml/s升至(14.0±4.5) ml/s,血清前列腺特異性抗原從術前(176.5±160.5)μg/L降至(2.0±1.0)μg/L,國際前列腺癥狀評分從術前(25.0±5.0)分降至(8.0±1.0)分,生活質量評分從術前(4.0±2.0)分降至(1.0±1.0)分.手術前、後比較差異均有統計學意義(t值分彆為9.502、7.371、5.238、8.350,P均＜0.05).隨訪3 ～18箇月,臨床癥狀明顯改善,排尿滿意,全部帶瘤存活.結論 PVP聯閤睪汍切除術加抗雄激素治療晚期前列腺癌常閤併膀胱齣口梗阻,能有效改善後尿道梗阻癥狀,提高瞭患者生活質量.
목적 평고응용록격광기화술(PVP)연합고환절제가항웅격소치료만기전렬선암병방광출구경조적효과.방법 회고성분석20례채용PVP연합고환절제가항웅격소치료만기전렬선암병방광출구경조환자적림상자료.결과 전부환자균수술치료성공.최대뇨류솔종술전(2.0±1.0) ml/s승지(14.0±4.5) ml/s,혈청전렬선특이성항원종술전(176.5±160.5)μg/L강지(2.0±1.0)μg/L,국제전렬선증상평분종술전(25.0±5.0)분강지(8.0±1.0)분,생활질량평분종술전(4.0±2.0)분강지(1.0±1.0)분.수술전、후비교차이균유통계학의의(t치분별위9.502、7.371、5.238、8.350,P균＜0.05).수방3 ～18개월,림상증상명현개선,배뇨만의,전부대류존활.결론 PVP연합고환절제술가항웅격소치료만기전렬선암상합병방광출구경조,능유효개선후뇨도경조증상,제고료환자생활질량.
Objective To evaluate the clinical efficacy of green light photoselective vaporization(PVP)combined testicular resection plus anti-androgen treatment on advanced prostate cancer and bladder outlet obstruction.Methods Twenty cases with PVP of advanced prostate cancer and bladder outlet obstruction were selected as our subjects,who underwent PVP testicular resection plus anti-androgen treatment.The clinical information was recorded.Results All patients were succeed through surgery.Maximum urinary flow rate (MFR) at the pre-operation was (2.0 ± 1.0) ml/s,and increased to (14.0 ± 4.5) ml/s after operation.Serum prostate specific antigen (PSA) was decreased from the preoperative (176.5 ± 160.5) μg/L to (2.0 ± 1.0)μg/L International prostate symptom score (IPSS) was from (25.0 ± 5.0) down to (8.0 ± 1.0) points.The quality of life (QOL) score was (4.0 ± 2.0) at pre-operation,higher than after operation (1.0 ± 1.0)points.There were significant differences between preoperative and postoperative (t =9.502,7.371,5.328,8.350,P ＜0.05).Every patient was followed up from 3 to 18 months.The improvements regarding of clinical symptoms were seen including voiding,and all patients survived with tumor.Conclusion Advanced prostate cancer associate with bladder outlet obstruction.The therapy plan of PVP joint testicular resection plus antiandrogen is proved to improve symptoms of urethral obstruction and patient quality of life.
