CAJ | 학술논문

目的：探讨伐昔洛韦联合咪喹莫特乳膏对预防频发性生殖器疱疹复发的疗效及安全性。方法：将2009年至2012年东莞市太平人民医院收治的102例频发性生殖器疱疹患者分为治疗组(52例)和对照组(50例)。两组均口服伐昔洛韦片450 mg，每日2次；治疗组加用咪喹莫特乳膏外用，每周3次；疗程均为3个月。观察两组患者治愈率、有效率和复发率。结果：治疗组痊愈率、总有效率略高于对照组，但差异无统计学意义(χ2＝0.812，P>0.05)。治疗组总复发率(36.5％)低于对照组总复发率(82.0％)，两组比较，差异有统计学意义(χ2＝9.781，P<0.05)。两组治疗期间均未发生严重不良反应。结论：伐昔洛韦联合咪喹莫特乳膏比单用伐昔洛韦更能减低频发性生殖器疱疹的复发率，值得临床推广。
목적：탐토벌석락위연합미규막특유고대예방빈발성생식기포진복발적료효급안전성。방법：장2009년지2012년동완시태평인민의원수치적102례빈발성생식기포진환자분위치료조(52례)화대조조(50례)。량조균구복벌석락위편450 mg，매일2차；치료조가용미규막특유고외용，매주3차；료정균위3개월。관찰량조환자치유솔、유효솔화복발솔。결과：치료조전유솔、총유효솔략고우대조조，단차이무통계학의의(χ2＝0.812，P>0.05)。치료조총복발솔(36.5％)저우대조조총복발솔(82.0％)，량조비교，차이유통계학의의(χ2＝9.781，P<0.05)。량조치료기간균미발생엄중불량반응。결론：벌석락위연합미규막특유고비단용벌석락위경능감저빈발성생식기포진적복발솔，치득림상추엄。
Objective:To investigate the efficacy and safety of valacyclovir and imiquimod cream for the treatment of recurrent genital herpes. Methods:Between 2009 and 2012, we allocated 102 patients with recurrent genital herpes who were admitted to Taiping People’ s Hospital of Dongguan to be treated with valacyclovir 450 mg twice daily alone (control group, n=50) or in combination with topical imiquimod cream thrice weekly for 3 months ( treatment group, n =52 ) . This entailed the comparison on the cure, effective and relapse rates. Results:The treatment group yielded numerically but not statistically higher cure and total effective rates than control group (both P>0. 05). However, treatment group was associated with a markedly lower rate of relapse (36. 5% vs. 82%, χ2 = 9. 781, P <0. 05 ) compared with control group. No serious adverse events were reported during the treatment. Conclusion:The combination of valacyclovir and imiquimod cream, compared with valacyclovir alone, is more and effective and safer for the treatment of recurrent genital herpes.