CAJ | 학술논문

目的比较伏立康唑与氟康唑治疗肺部念珠菌感染的疗效与安全性.方法 79例肺念珠菌感染患者按照住院号顺序分为伏立康唑组与氟康唑组,观察患者症状和体征变化,评价感染治愈率及治疗安全性.结果伏立康唑组总体有效率为93.1％,明显高于氟康唑组的65.9％(x2=7.51,P＜0.01),痊愈率分别为65.1％和36.1％,差异均有统计学意义(x2 =6.60,P＜0.05).伏立康唑组不良反应发生率为14.0％,氟康唑组不良反应发生率为16.7％,两组差异无统计学意义(P＞0.05).结论伏立康唑治疗肺部念珠菌感染效果优于氟康唑,两者安全性均较高.
목적 비교복립강서여불강서치료폐부념주균감염적료효여안전성.방법 79례폐념주균감염환자안조주원호순서분위복립강서조여불강서조,관찰환자증상화체정변화,평개감염치유솔급치료안전성.결과 복립강서조총체유효솔위93.1％,명현고우불강서조적65.9％(x2=7.51,P＜0.01),전유솔분별위65.1％화36.1％,차이균유통계학의의(x2 =6.60,P＜0.05).복립강서조불량반응발생솔위14.0％,불강서조불량반응발생솔위16.7％,량조차이무통계학의의(P＞0.05).결론 복립강서치료폐부념주균감염효과우우불강서,량자안전성균교고.
Objective To observe the efficacy and safety of voriconazole in the treatment for the patients infectedwith Candida species.Methods 79 patients were randomly divided into voriconazole treatment group and fluconasole treatment group.And they were enrolled and were administered voriconazole.Results The total effective rate of experimental group was 93.1％,and that of control group was 65.9％ and the difference was significant(P ＜0.05).the risk factors of the two groups showed no obvious difference.the adverse reaction incidence rate in voriconazole treatment group was 16.7％,And that in fluconazole treatment group was 14.0％,there was no significant difference between the two groups.Conclusion The application of voriconazole can receive better effect than that of fluconasole.And it has good clinical safety,and voriconazole is worthy of application in clinic for Candida infection.