交通医学
交通醫學
교통의학
MEDICAL JOURNAL OF COMMUNICATIONS
2014年
1期
27-29
,共3页
施颖琦%陆飞%仇建伟%葛振明%王亚民%钱俊波
施穎琦%陸飛%仇建偉%葛振明%王亞民%錢俊波
시영기%륙비%구건위%갈진명%왕아민%전준파
溃疡性结肠炎%血清细胞间粘附分子-1%酶联免疫吸附试验
潰瘍性結腸炎%血清細胞間粘附分子-1%酶聯免疫吸附試驗
궤양성결장염%혈청세포간점부분자-1%매련면역흡부시험
ulcerative colitis%serum intercellular adhesion molecule-1 (sICAM-1)%enzyme-linked immunosorbent assay(ELISA)
目的：检测溃疡性结肠炎患者血清可溶性细胞间粘附分子-1（sICAM-1）水平的变化，探讨sICAM-1对溃疡性结肠炎疾病进展程度的作用。方法：溃疡性结肠炎32例、健康体检者20例为研究对象，采用ELISA法检测血清SICAM-1水平，分析其与临床分型、病变范围、疾病严重程度、肠外表现与CRP、ESR的关系。结果：（1）sICAM-1水平：溃疡性结肠炎组305.34±73.33ng/mL，对照组189.72±56.46ng/mL，两组比较差异有统计学意义（P<0.05）。（2） sICAM-1与临床分型关系：初发型15例sICAM-1283.45±90.02ng/mL，慢性反复发作型17例sICAM-1为292.36±78.91ng/mL，两者比较差异无统计学意义（P>0.05）。（3）sICAM-1与病变范围关系：E1（直肠）14例，E2（左半结肠）12例，E3（广泛结肠）6例，其sICAM-1分别为264.22±89.43ng/mL、275.36±97.91ng/mL、336.45±73.02ng/mL，E1组与E2组比较差异无统计学意义（P>0.05）,E3组与E1、E2组比较差异有统计学意义（P<0.05）。（4）sICAM-1与疾病程度关系：轻度10例，中度16例，重度6例，其sICAM-1分别264.22±67.27ng/mL、302.36±54.34ng/mL、336.45±73.02ng/mL，3组间比较差异有统计学意义（P<0.05）。（5）sICAM-1肠外表现：肠外表现11例，sICAM-1为312.23±89.02ng/mL。无肠外表现21例sICAM-1为295.11±65.02ng/mL，两者比较差异无统计学意义（P>0.05）。（6）sICAM-1水平与CRP、ESR的关系：sICAM-1与CRP成正相关，r值为0.561（P<0.05）；sICAM-1与ERS成正相关，r值为0.478（P<0.05）。结论：sICAM-1水平与UC病变范围及严重程度相关，可作为评估UC炎症程度指标之一。
目的：檢測潰瘍性結腸炎患者血清可溶性細胞間粘附分子-1（sICAM-1）水平的變化，探討sICAM-1對潰瘍性結腸炎疾病進展程度的作用。方法：潰瘍性結腸炎32例、健康體檢者20例為研究對象，採用ELISA法檢測血清SICAM-1水平，分析其與臨床分型、病變範圍、疾病嚴重程度、腸外錶現與CRP、ESR的關繫。結果：（1）sICAM-1水平：潰瘍性結腸炎組305.34±73.33ng/mL，對照組189.72±56.46ng/mL，兩組比較差異有統計學意義（P<0.05）。（2） sICAM-1與臨床分型關繫：初髮型15例sICAM-1283.45±90.02ng/mL，慢性反複髮作型17例sICAM-1為292.36±78.91ng/mL，兩者比較差異無統計學意義（P>0.05）。（3）sICAM-1與病變範圍關繫：E1（直腸）14例，E2（左半結腸）12例，E3（廣汎結腸）6例，其sICAM-1分彆為264.22±89.43ng/mL、275.36±97.91ng/mL、336.45±73.02ng/mL，E1組與E2組比較差異無統計學意義（P>0.05）,E3組與E1、E2組比較差異有統計學意義（P<0.05）。（4）sICAM-1與疾病程度關繫：輕度10例，中度16例，重度6例，其sICAM-1分彆264.22±67.27ng/mL、302.36±54.34ng/mL、336.45±73.02ng/mL，3組間比較差異有統計學意義（P<0.05）。（5）sICAM-1腸外錶現：腸外錶現11例，sICAM-1為312.23±89.02ng/mL。無腸外錶現21例sICAM-1為295.11±65.02ng/mL，兩者比較差異無統計學意義（P>0.05）。（6）sICAM-1水平與CRP、ESR的關繫：sICAM-1與CRP成正相關，r值為0.561（P<0.05）；sICAM-1與ERS成正相關，r值為0.478（P<0.05）。結論：sICAM-1水平與UC病變範圍及嚴重程度相關，可作為評估UC炎癥程度指標之一。
목적：검측궤양성결장염환자혈청가용성세포간점부분자-1（sICAM-1）수평적변화，탐토sICAM-1대궤양성결장염질병진전정도적작용。방법：궤양성결장염32례、건강체검자20례위연구대상，채용ELISA법검측혈청SICAM-1수평，분석기여림상분형、병변범위、질병엄중정도、장외표현여CRP、ESR적관계。결과：（1）sICAM-1수평：궤양성결장염조305.34±73.33ng/mL，대조조189.72±56.46ng/mL，량조비교차이유통계학의의（P<0.05）。（2） sICAM-1여림상분형관계：초발형15례sICAM-1283.45±90.02ng/mL，만성반복발작형17례sICAM-1위292.36±78.91ng/mL，량자비교차이무통계학의의（P>0.05）。（3）sICAM-1여병변범위관계：E1（직장）14례，E2（좌반결장）12례，E3（엄범결장）6례，기sICAM-1분별위264.22±89.43ng/mL、275.36±97.91ng/mL、336.45±73.02ng/mL，E1조여E2조비교차이무통계학의의（P>0.05）,E3조여E1、E2조비교차이유통계학의의（P<0.05）。（4）sICAM-1여질병정도관계：경도10례，중도16례，중도6례，기sICAM-1분별264.22±67.27ng/mL、302.36±54.34ng/mL、336.45±73.02ng/mL，3조간비교차이유통계학의의（P<0.05）。（5）sICAM-1장외표현：장외표현11례，sICAM-1위312.23±89.02ng/mL。무장외표현21례sICAM-1위295.11±65.02ng/mL，량자비교차이무통계학의의（P>0.05）。（6）sICAM-1수평여CRP、ESR적관계：sICAM-1여CRP성정상관，r치위0.561（P<0.05）；sICAM-1여ERS성정상관，r치위0.478（P<0.05）。결론：sICAM-1수평여UC병변범위급엄중정도상관，가작위평고UC염증정도지표지일。
Objective:To determine the serum levels of intercellular adhesion molecule-1(sICAM-1) in patients with ulcerative colitis and to investigate the contributions of sICAM-1 in pathogenesis of UC. Methods: The serum ICAM-1 concentrations were determined by enzyme-linked immunosorbent assay in 32 patients with UC and 20 healthy controls at the time of admission.The relationships between the sICAM-1 levels and the clinical type, the extent, the severity, Extrain-testinal complications, CRP and ESR were analized. Results:(1)the levels of sICAM-1:The mean value of sICAM-1 level in the UC group(305.34±73.33ng/mL)was significantly higher than in the health group(189.72±56.46ng/mL)(P<0.05).(2) the relationgships between sICAM-1 and clinical classification: There were no remarkable relationships between the levels of sICAM-1 in 15 patients of the first attack group (283.45 ±90.02ng/mL) and 17 patients of the recurrent attack group (292.36±78.91ng/mL)(P>0.05). (3) the relationgships between sICAM-1 and the extent of disease:14 patients in E1(the rectal group),12 patients in E2(the sigmoid group),6 patients in E3(the extensive colonic group). There were no remark-able relationships between sICAM-1 in the E1 group (264.22±89.43ng/mL) and the E2 group (275.36±97.91ng/mL) (P>0.05), but the levels of sICAM-1 in the E3 (336.45±73.02ng/mL)group was significantly higher than in the E1group and the E2 group(P<0.05). (4) the relationgships between sICAM-1 and different degrees of severity of disease: 10 patients in the light group (264.22 ±67.27ng/mL), 16patients in the moderate group (302.36 ±54.34ng/mL), 6 patients in the severe group (336.45±73.02ng/mL), the levels of sICAM-1 between the three groups with differernt degrees of severity of UC were significantly different(P<0.05). (5) the relationgships between sICAM-1 and Extraintestinal complications:11 patients with extraintestinal complications (312.23 ±89.02ng/mL), 21 patients without extraintestinal complications (295.11 ±65.02ng/mL), there were no remarkable relationships between sICAM-1 and Extraintestinal complications (P>0.05).(6) the relationgships between sICAM-1 and CRP and ESR:sICAM-1 was positively correlated with CRP(r=0.561,P<0.05)) and ESR(r=0.478, P<0.05). Conclusions: sICAM-1 levels were correlated with the extent and the severity of UC. The measurement of sICAM-1 may be valuable markers to evaluate the severity for patients with ulcerative colitis.
