CAJ | 학술논문

目的：探讨TRA2B在非小细胞肺癌中的表达情况，并分析其与肺癌临床病理特征之间的关系。方法：Western blot检测6对肺癌组织和癌旁非肿瘤组织中TRA2B的蛋白表达水平，免疫组织化学染色分析93例非小细胞肺癌组织中TRA2B的表达。结果：TRA2B在肺癌组织中表达水平高于癌旁非肿瘤组织，TRA2B的表达情况与肺癌的分化程度以及临床分级相关（P<0.05）。结论：TRA2B在非小细胞肺癌中表达上调，提示TRA2B可能可以作为诊断肺癌的潜在标记物以及治疗的潜在靶点。
목적：탐토TRA2B재비소세포폐암중적표체정황，병분석기여폐암림상병리특정지간적관계。방법：Western blot검측6대폐암조직화암방비종류조직중TRA2B적단백표체수평，면역조직화학염색분석93례비소세포폐암조직중TRA2B적표체。결과：TRA2B재폐암조직중표체수평고우암방비종류조직，TRA2B적표체정황여폐암적분화정도이급림상분급상관（P<0.05）。결론：TRA2B재비소세포폐암중표체상조，제시TRA2B가능가이작위진단폐암적잠재표기물이급치료적잠재파점。
Objective: To analyze the expression of TRA2B in Non-small cell lung cancer and the relationship be-tween the expression of TRA2B and its clinicopathologic variables. Methods: The expression of TRA2B in 6 pairs of tu-mor tissues and adjacent nontumorous tissues was detected by Western blot, and immunohistochemistry technique was used to analyze the expression of TRA2B in 93 lung cancer samples. Results: The expression of TRA2B was higeher in lung cancer tissues than in adjacent nontumorous tissues and the expression of TRA2B had a correlation with the clinical stage and histological differentiation. Conclusion: TRA2B was overexpressed in lung cancer and TRA2B might be a potential marker for lung cancer diagnosis and a potential target for lung cancer therapy.